Macrophage Activation Syndrome in Children: Diagnosis and Management

Macrophage activation syndrome is a severe yet under-recognized complication encountered in pediatric rheumatology. It manifests as secondary hemophagocytic lymphohistiocytosis leading to a hyper-inflammatory state resulting from an underlying cytokine storm. If unchecked, it may lead to multiorgan...

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Detalles Bibliográficos
Autores principales: Bagri, Narendra Kumar, Gupta, Latika, Sen, Ethan S., Ramanan, A. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer India 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732159/
https://www.ncbi.nlm.nih.gov/pubmed/33772536
http://dx.doi.org/10.1007/s13312-021-2399-8
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author Bagri, Narendra Kumar
Gupta, Latika
Sen, Ethan S.
Ramanan, A. V.
author_facet Bagri, Narendra Kumar
Gupta, Latika
Sen, Ethan S.
Ramanan, A. V.
author_sort Bagri, Narendra Kumar
collection PubMed
description Macrophage activation syndrome is a severe yet under-recognized complication encountered in pediatric rheumatology. It manifests as secondary hemophagocytic lymphohistiocytosis leading to a hyper-inflammatory state resulting from an underlying cytokine storm. If unchecked, it may lead to multiorgan failure and mortality. Early diagnosis and timely initiation of specific therapy is pivotal for a successful outcome. This review outlines the key clinical and laboratory features and management of macrophage activation syndrome.
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spelling pubmed-87321592022-01-06 Macrophage Activation Syndrome in Children: Diagnosis and Management Bagri, Narendra Kumar Gupta, Latika Sen, Ethan S. Ramanan, A. V. Indian Pediatr Review Article Macrophage activation syndrome is a severe yet under-recognized complication encountered in pediatric rheumatology. It manifests as secondary hemophagocytic lymphohistiocytosis leading to a hyper-inflammatory state resulting from an underlying cytokine storm. If unchecked, it may lead to multiorgan failure and mortality. Early diagnosis and timely initiation of specific therapy is pivotal for a successful outcome. This review outlines the key clinical and laboratory features and management of macrophage activation syndrome. Springer India 2021-03-26 2021 /pmc/articles/PMC8732159/ /pubmed/33772536 http://dx.doi.org/10.1007/s13312-021-2399-8 Text en © Indian Academy of Pediatrics 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review Article
Bagri, Narendra Kumar
Gupta, Latika
Sen, Ethan S.
Ramanan, A. V.
Macrophage Activation Syndrome in Children: Diagnosis and Management
title Macrophage Activation Syndrome in Children: Diagnosis and Management
title_full Macrophage Activation Syndrome in Children: Diagnosis and Management
title_fullStr Macrophage Activation Syndrome in Children: Diagnosis and Management
title_full_unstemmed Macrophage Activation Syndrome in Children: Diagnosis and Management
title_short Macrophage Activation Syndrome in Children: Diagnosis and Management
title_sort macrophage activation syndrome in children: diagnosis and management
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732159/
https://www.ncbi.nlm.nih.gov/pubmed/33772536
http://dx.doi.org/10.1007/s13312-021-2399-8
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