Cargando…

The emerging roles of Gα12/13 proteins on the hallmarks of cancer in solid tumors

G12 proteins comprise a subfamily of G-alpha subunits of heterotrimeric GTP-binding proteins (G proteins) that link specific cell surface G protein-coupled receptors (GPCRs) to downstream signaling molecules and play important roles in human physiology. The G12 subfamily contains two family members:...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rasheed, Suhail Ahmed Kabeer, Subramanyan, Lalitha Vaishnavi, Lim, Wei Kiang, Udayappan, Udhaya Kumari, Wang, Mei, Casey, Patrick J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732267/ https://www.ncbi.nlm.nih.gov/pubmed/34689178 http://dx.doi.org/10.1038/s41388-021-02069-w

Ejemplares similares

c-Jun Contributes to Transcriptional Control of GNA12 Expression in Prostate Cancer Cells
por: Udayappan, Udhaya Kumari, et al.
Publicado: (2017)

Breast cancer cell invasion mediated by Gα12 signaling involves expression of interleukins-6 and −8, and matrix metalloproteinase-2
por: Chia, Crystal Y, et al.
Publicado: (2014)

MicroRNA-31 controls G protein alpha-13 (GNA13) expression and cell invasion in breast cancer cells
por: Rasheed, Suhail Ahmed Kabeer, et al.
Publicado: (2015)

Gα(12) and Gα(13): Versatility in Physiology and Pathology
por: Guo, Paipai, et al.
Publicado: (2022)

Gα(12/13) signaling in metabolic diseases
por: Yang, Yoon Mee, et al.
Publicado: (2020)

Receptor selectivity between the G proteins Gα(12) and Gα(13) is defined by a single leucine-to-isoleucine variation
por: Mackenzie, Amanda E., et al.
Publicado: (2019)

Hallmarks of cancer and hallmarks of aging
por: Blagosklonny, Mikhail V.
Publicado: (2022)

Loss of G(α12/13) exacerbates apical area dependence of actomyosin contractility
por: Xie, Shicong, et al.
Publicado: (2016)

GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers
por: Rasheed, Suhail Ahmed Kabeer, et al.
Publicado: (2017)

The PAR2 inhibitor I-287 selectively targets Gα(q) and Gα(12/13) signaling and has anti-inflammatory effects
por: Avet, Charlotte, et al.
Publicado: (2020)

Gα(12/13) regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton
por: Lin, Fang, et al.
Publicado: (2009)

Cardiovascular Dementia - A Different Perspective
por: Kumari, Udhaya, et al.
Publicado: (2010)

The Role of Merkel Cell Polyomavirus and Other Human Polyomaviruses in Emerging Hallmarks of Cancer
por: Moens, Ugo, et al.
Publicado: (2015)

The HIF-1α as a Potent Inducer of the Hallmarks in Gastric Cancer
por: Ucaryilmaz Metin, Cemre, et al.
Publicado: (2022)

The “hallmark” cells
por: Pandiar, Deepak, et al.
Publicado: (2019)

Hallmarks of ribosomopathies
por: Kampen, Kim R, et al.
Publicado: (2020)

Hallmarks of exosomes
por: Dilsiz, Nihat
Publicado: (2021)

The hallmarks of autism
por: Crespi, Bernard J.
Publicado: (2022)

Leucine-Rich Repeat Kinase 2-Linked Parkinson’s Disease: Clinical and Molecular Findings
por: Kumari, Udhaya, et al.
Publicado: (2010)

Immunoglobulin G1 Fc glycosylation as an early hallmark of severe COVID-19
por: Pongracz, Tamas, et al.
Publicado: (2022)

Genomic hallmarks and therapeutic implications of G0 cell cycle arrest in cancer
por: Wiecek, Anna J., et al.
Publicado: (2023)

G(12/13) Signaling Pathways Substitute for Integrin αIIbβ3-Signaling for Thromboxane Generation in Platelets
por: Bhavaraju, Kamala, et al.
Publicado: (2011)

Drosophila Ric-8 interacts with the Gα(12/13) subunit, Concertina, during activation of the Folded gastrulation pathway
por: Peters, Kimberly A., et al.
Publicado: (2013)

The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα(12/13) and RhoA
por: Ackerman, Sarah D., et al.
Publicado: (2015)

Determinant role for the gep oncogenes, Gα12/13, in ovarian cancer cell proliferation and xenograft tumor growth
por: Ha, Ji Hee, et al.
Publicado: (2015)

Hallmarks of glycosylation in cancer
por: Munkley, Jennifer, et al.
Publicado: (2016)

Melatonin and Cancer Hallmarks
por: Talib, Wamidh H.
Publicado: (2018)

Hallmarks of Aging in the Liver
por: Hunt, Nicholas J., et al.
Publicado: (2019)

Hallmarks of senescence and aging
por: Dodig, Slavica, et al.
Publicado: (2019)

The microbiome and the hallmarks of cancer
por: Fulbright, Laura E., et al.
Publicado: (2017)

The Hallmarks of Flavonoids in Cancer
por: Ponte, Luis Gustavo Saboia, et al.
Publicado: (2021)

Heparanase and the hallmarks of cancer
por: Jayatilleke, Krishnath M., et al.
Publicado: (2020)

The Evolution of the Hallmarks of Aging
por: Lemoine, Maël
Publicado: (2021)

An Update to Hallmarks of Cancer
por: Ravi, Swapna, et al.
Publicado: (2022)

Heterotrimeric G-protein alpha-12 (Gα12) subunit promotes oral cancer metastasis
por: Gan, Chai Phei, et al.
Publicado: (2014)

The Complex and Critical Role of Glycine 12 (G12) in Beta-Connexins of Human Skin
por: Bailey, Rasheed A., et al.
Publicado: (2021)

The PARP Enzyme Family and the Hallmarks of Cancer Part 1. Cell Intrinsic Hallmarks
por: Demény, Máté A., et al.
Publicado: (2021)

Essential roles of Gα(12/13) signaling in distinct cell behaviors driving zebrafish convergence and extension gastrulation movements
por: Lin, Fang, et al.
Publicado: (2005)

Heterochromatin protein 1α: a hallmark of cell proliferation relevant to clinical oncology
por: De Koning, Leanne, et al.
Publicado: (2009)

Overlap in signaling between Smoothened and the α subunit of the heterotrimeric G protein G(13)
por: Guo, Xueshui, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ct54i3i2s0tark91uu9fakikh6