Neoadjuvant STING Activation, Extended Half-life IL2, and Checkpoint Blockade Promote Metastasis Clearance via Sustained NK-cell Activation

Combination immunotherapy treatments that recruit both innate and adaptive immunity have the potential to increase cancer response rates by engaging a more complete repertoire of effector mechanisms. Here, we combined intratumoral STimulator of INterferon Genes (STING) agonist therapy with systemica...

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Detalles Bibliográficos
Autores principales: Milling, Lauren E., Garafola, Daniel, Agarwal, Yash, Wu, Shengwei, Thomas, Ayush, Donahue, Nathan, Adams, Josetta, Thai, Nikki, Suh, Heikyung, Irvine, Darrell J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732307/
https://www.ncbi.nlm.nih.gov/pubmed/34686488
http://dx.doi.org/10.1158/2326-6066.CIR-21-0247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732307/
https://www.ncbi.nlm.nih.gov/pubmed/34686488
http://dx.doi.org/10.1158/2326-6066.CIR-21-0247

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