The PI3K/mTOR inhibitor Gedatolisib eliminates dormant breast cancer cells in organotypic culture, but fails to prevent metastasis in preclinical settings

Dormant, disseminated tumor cells (DTCs) are thought to be the source of breast cancer metastases several years or even decades after initial treatment. To date, a selective therapy that leads to their elimination has not been discovered. While dormant DTCs resist chemotherapy, evidence suggests tha...

Descripción completa

Detalles Bibliográficos
Autores principales: Shor, Ryann E., Dai, Jinxiang, Lee, Sun‐Young, Pisarsky, Laura, Matei, Irina, Lucotti, Serena, Lyden, David, Bissell, Mina J., Ghajar, Cyrus M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732345/
https://www.ncbi.nlm.nih.gov/pubmed/34058066
http://dx.doi.org/10.1002/1878-0261.13031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732345/
https://www.ncbi.nlm.nih.gov/pubmed/34058066
http://dx.doi.org/10.1002/1878-0261.13031

Ejemplares similares