Cancer‐associated fibroblasts educate normal fibroblasts to facilitate cancer cell spreading and T‐cell suppression

In some tumors, a small number of cancer cells are scattered in a large fibrotic stroma. Here, we demonstrate a novel mechanism for expansion of pro‐tumor fibroblasts via cancer‐associated fibroblast (CAF)‐mediated education of normal fibroblasts (NFs). When NFs were incubated with conditioned mediu...

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Detalles Bibliográficos
Autores principales: Itoh, Go, Takagane, Kurara, Fukushi, Yuma, Kuriyama, Sei, Umakoshi, Michinobu, Goto, Akiteru, Yanagihara, Kazuyoshi, Yashiro, Masakazu, Tanaka, Masamitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732346/
https://www.ncbi.nlm.nih.gov/pubmed/34379869
http://dx.doi.org/10.1002/1878-0261.13077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732346/
https://www.ncbi.nlm.nih.gov/pubmed/34379869
http://dx.doi.org/10.1002/1878-0261.13077

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