Cargando…

Cancer‐associated fibroblasts educate normal fibroblasts to facilitate cancer cell spreading and T‐cell suppression

In some tumors, a small number of cancer cells are scattered in a large fibrotic stroma. Here, we demonstrate a novel mechanism for expansion of pro‐tumor fibroblasts via cancer‐associated fibroblast (CAF)‐mediated education of normal fibroblasts (NFs). When NFs were incubated with conditioned mediu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Itoh, Go, Takagane, Kurara, Fukushi, Yuma, Kuriyama, Sei, Umakoshi, Michinobu, Goto, Akiteru, Yanagihara, Kazuyoshi, Yashiro, Masakazu, Tanaka, Masamitsu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732346/ https://www.ncbi.nlm.nih.gov/pubmed/34379869 http://dx.doi.org/10.1002/1878-0261.13077

Ejemplares similares

CCDC85A is regulated by miR-224-3p and augments cancer cell resistance to endoplasmic reticulum stress
por: Takahashi, So, et al.
Publicado: (2023)

Expression of asporin reprograms cancer cells to acquire resistance to oxidative stress
por: Sasaki, Yuto, et al.
Publicado: (2021)

Pigment Epithelium Derived Factor Is Involved in the Late Phase of Osteosarcoma Metastasis by Increasing Extravasation and Cell-Cell Adhesion
por: Kuriyama, Sei, et al.
Publicado: (2022)

The low expression of miR-451 predicts a worse prognosis in non-small cell lung cancer cases
por: Goto, Akiteru, et al.
Publicado: (2017)

Cancer cells with high-metastatic potential promote a glycolytic shift in activated fibroblasts
por: Kogure, Akiko, et al.
Publicado: (2020)

Identification of anti‐cancer chemical compounds using Xenopus embryos
por: Tanaka, Masamitsu, et al.
Publicado: (2016)

Stromal Fibroblasts Mediate Extracellular Matrix Remodeling and Invasion of Scirrhous Gastric Carcinoma Cells
por: Yamaguchi, Hideki, et al.
Publicado: (2014)

MicroRNA-143 regulates collagen type III expression in stromal fibroblasts of scirrhous type gastric cancer
por: Naito, Yutaka, et al.
Publicado: (2014)

Cancer extracellular vesicles contribute to stromal heterogeneity by inducing chemokines in cancer-associated fibroblasts
por: Naito, Yutaka, et al.
Publicado: (2019)

Crosstalk Between Cancer Associated Fibroblasts and Cancer Cells in Scirrhous Type Gastric Cancer
por: Miki, Yuichiro, et al.
Publicado: (2020)

CD9-positive exosomes from cancer-associated fibroblasts stimulate the migration ability of scirrhous-type gastric cancer cells
por: Miki, Yuichiro, et al.
Publicado: (2018)

Interleukin-8 produced from cancer-associated fibroblasts suppresses proliferation of the OCUCh-LM1 cancer cell line
por: Tanaka, Ryota, et al.
Publicado: (2022)

MicroRNA-21 in cancer-associated fibroblasts supports lung adenocarcinoma progression
por: Kunita, Akiko, et al.
Publicado: (2018)

Disorganization of intercalated discs in dilated cardiomyopathy
por: Ito, Yukinobu, et al.
Publicado: (2021)

Role of Orthotopic Fibroblasts in the Development of Scirrhous Gastric Carcinoma
por: Yashiro, Masakazu, et al.
Publicado: (1994)

The heterogeneity of cancer‐associated fibroblast subpopulations: Their origins, biomarkers, and roles in the tumor microenvironment
por: Yamamoto, Yurie, et al.
Publicado: (2022)

Differential responses of scirrhous and well-differentiated gastric cancer cells to orthotopic fibroblasts.
por: Yashiro, M., et al.
Publicado: (1996)

A case of Russell body gastritis with multifocal lesions
por: Umakoshi, Michinobu, et al.
Publicado: (2020)

Transforming Growth Factor‐β and Hepatocyte Growth Factor Produced by Gastric Fibroblasts Stimulate the Invasiveness of Scirrhous Gastric Cancer Cells
por: Inoue, Tohru, et al.
Publicado: (1997)

Collision of Epstein–Barr virus-positive and -negative gastric cancer, diagnosed by molecular analysis: a case report
por: Miyabe, Ken, et al.
Publicado: (2021)

Clinical difference between fibroblast growth factor receptor 2 subclass, type IIIb and type IIIc, in gastric cancer
por: Yashiro, Masakazu, et al.
Publicado: (2021)

Induction of spreading during fibroblast movement
Publicado: (1979)

Dynamic microtubules drive fibroblast spreading
por: Tvorogova, Anna, et al.
Publicado: (2018)

Pancreatic Fibroblasts Stimulate the Motility of Pancreatic Cancer Cells through IGF1/IGF1R Signaling under Hypoxia
por: Hirakawa, Toshiki, et al.
Publicado: (2016)

Macrophage numbers in the marginal area of sarcomas predict clinical prognosis
por: Umakoshi, Michinobu, et al.
Publicado: (2023)

Decoding Metabolic Symbiosis between Pancreatic Cancer Cells and Cancer-Associated Fibroblasts Using Cultured Tumor Microenvironment
por: Nihashi, Yuma, et al.
Publicado: (2023)

Fibroblasts are the most suitable cell source for regenerative medicine due to their high intracellular fibroblast growth factor 2 content
por: Yanagihara, Masashi, et al.
Publicado: (2023)

Fibronectin glycosylation modulates fibroblast adhesion and spreading
Publicado: (1986)

Evidence for synovial fibroblasts spreading rheumatoid arthritis
por: Müller-Ladner, Ulf, et al.
Publicado: (2012)

Neutralizing Antibodies Limit Cell-Associated Spread of Human Cytomegalovirus in Epithelial Cells and Fibroblasts
por: Reuter, Nina, et al.
Publicado: (2022)

Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth
por: Shiga, Kazuyoshi, et al.
Publicado: (2015)

Fibroblast growth factors
por: Ornitz, David M, et al.
Publicado: (2001)

Saracatinib impairs the peritoneal dissemination of diffuse-type gastric carcinoma cells resistant to Met and fibroblast growth factor receptor inhibitors
por: Yamaguchi, Hideki, et al.
Publicado: (2014)

Single-Cell Transcriptomic Analysis of Tumor-Derived Fibroblasts and Normal Tissue-Resident Fibroblasts Reveals Fibroblast Heterogeneity in Breast Cancer
por: Sebastian, Aimy, et al.
Publicado: (2020)

Causal Effect of Fibroblast Growth Factor 23 on Osteoporosis and Cardiometabolic Disorders: A Mendelian Randomization Study
por: Yokomoto-Umakoshi, Maki, et al.
Publicado: (2021)

Cancer-associated fibroblasts in the single-cell era
por: Lavie, Dor, et al.
Publicado: (2022)

Exosomes derived from Piwil2-induced cancer stem cells transform fibroblasts into cancer-associated fibroblasts
por: Zhang, Dan, et al.
Publicado: (2020)

Exosomes derived from Piwil2-induced cancer stem cells transform fibroblasts into cancer-associated fibroblasts
por: Zhang, Dan, et al.
Publicado: (2022)

Nuclear Localization of Fibroblast Growth Factor Receptor 1 in Breast Cancer Cells Interacting with Cancer Associated Fibroblasts
por: Suh, Jinyoung, et al.
Publicado: (2022)

Direct cancer–stromal interaction increases fibroblast proliferation and enhances invasive properties of scirrhous-type gastric carcinoma cells
por: Semba, S, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_lsto1fmqbk8b8i1t6ieb421mc7