Increased glycolysis affects β-cell function and identity in aging and diabetes

OBJECTIVE: Age is a risk factor for type 2 diabetes (T2D). We aimed to elucidate whether β-cell glucose metabolism is altered with aging and contributes to T2D. METHODS: We used senescence-accelerated mice (SAM), C57BL/6J (B6) mice, and ob/ob mice as aging models. As a diabetes model, we used db/db...

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Detalles Bibliográficos
Autores principales: Murao, Naoya, Yokoi, Norihide, Takahashi, Harumi, Hayami, Tomohide, Minami, Yasuhiro, Seino, Susumu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732780/
https://www.ncbi.nlm.nih.gov/pubmed/34871777
http://dx.doi.org/10.1016/j.molmet.2021.101414

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