High chromosome instability identified by low-pass whole-genome sequencing assay is associated with TP53 copy loss and worse prognosis in BRCA1 germline mutation breast cancer

BACKGROUND: Though BRCA1 mutation is the most susceptible factor of breast cancer, its prognostic value is disputable. Here in this study, we use a novel method which based on whole-genome analysis to evaluate the chromosome instability (CIN) value and identified the potential relationship between C...

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Detalles Bibliográficos
Autores principales: Zhu, Liang, Pan, Jia-Ni, Qian, Ziliang, Ye, Wei-Wu, Wang, Xiao-Jia, Cao, Wen-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732803/
https://www.ncbi.nlm.nih.gov/pubmed/34403063
http://dx.doi.org/10.1007/s12282-021-01286-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732803/
https://www.ncbi.nlm.nih.gov/pubmed/34403063
http://dx.doi.org/10.1007/s12282-021-01286-1

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