Immunisation with UB-312 in the Thy1SNCA mouse prevents motor performance deficits and oligomeric α-synuclein accumulation in the brain and gut

Alpha synuclein has a key role in the pathogenesis of Parkinson’s disease (PD), Dementia with Lewy Bodies (LBD) and Multiple System Atrophy (MSA). Immunotherapies aiming at neutralising toxic αSyn species are being investigated in the clinic as potential disease modifying therapies for PD and other...

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Detalles Bibliográficos
Autores principales: Nimmo, Jacqui T., Smith, Harry, Wang, Chang Yi, Teeling, Jessica L., Nicoll, James A. R., Verma, Ajay, Dodart, Jean-Cosme, Liu, Zhi, Lin, Feng, Carare, Roxana O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732825/
https://www.ncbi.nlm.nih.gov/pubmed/34741635
http://dx.doi.org/10.1007/s00401-021-02381-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732825/
https://www.ncbi.nlm.nih.gov/pubmed/34741635
http://dx.doi.org/10.1007/s00401-021-02381-5

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