Novel interaction between neurotrophic factor-α1/carboxypeptidase E and serotonin receptor, 5-HTR1E, protects human neurons against oxidative/neuroexcitotoxic stress via β-arrestin/ERK signaling

Protecting neurons from death during oxidative and neuroexcitotoxic stress is key for preventing cognitive dysfunction. We uncovered a novel neuroprotective mechanism involving interaction between neurotrophic factor-α1 (NF-α1/carboxypeptidase E, CPE) and human 5-HTR1E, a G protein-coupled serotonin...

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Detalles Bibliográficos
Autores principales: Sharma, Vinay Kumar, Yang, Xuyu, Kim, Soo-Kyung, Mafi, Amirhossein, Saiz-Sanchez, Daniel, Villanueva-Anguita, Patricia, Xiao, Lan, Toulabi, Leila, Inoue, Asuka, Goddard, William A., Loh, Y. Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732845/
https://www.ncbi.nlm.nih.gov/pubmed/34966948
http://dx.doi.org/10.1007/s00018-021-04021-3

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