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Comparison of Pupil Dilation Responses to Unexpected Sounds in Monkeys and Humans
Pupil dilation in response to unexpected stimuli has been well documented in human as well as in non-human primates; however, this phenomenon has not been systematically compared between the species. This analogy is also crucial for the role of non-human primates as an animal model to investigate ne...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732861/ https://www.ncbi.nlm.nih.gov/pubmed/35002851 http://dx.doi.org/10.3389/fpsyg.2021.754604 |
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author | Selezneva, Elena Brosch, Michael Rathi, Sanchit Vighneshvel, T. Wetzel, Nicole |
author_facet | Selezneva, Elena Brosch, Michael Rathi, Sanchit Vighneshvel, T. Wetzel, Nicole |
author_sort | Selezneva, Elena |
collection | PubMed |
description | Pupil dilation in response to unexpected stimuli has been well documented in human as well as in non-human primates; however, this phenomenon has not been systematically compared between the species. This analogy is also crucial for the role of non-human primates as an animal model to investigate neural mechanisms underlying the processing of unexpected stimuli and their evoked pupil dilation response. To assess this qualitatively, we used an auditory oddball paradigm in which we presented subjects a sequence of the same sounds followed by occasional deviants while we measured their evoked pupil dilation response (PDR). We used deviants (a frequency deviant, a pink noise burst, a monkey vocalization and a whistle sound) which differed in the spectral composition and in their ability to induce arousal from the standard. Most deviants elicited a significant pupil dilation in both species with decreased peak latency and increased peak amplitude in monkeys compared to humans. A temporal Principal Component Analysis (PCA) revealed two components underlying the PDRs in both species. The early component is likely associated to the parasympathetic nervous system and the late component to the sympathetic nervous system, respectively. Taken together, the present study demonstrates a qualitative similarity between PDRs to unexpected auditory stimuli in macaque and human subjects suggesting that macaques can be a suitable model for investigating the neuronal bases of pupil dilation. However, the quantitative differences in PDRs between species need to be investigated in further comparative studies. |
format | Online Article Text |
id | pubmed-8732861 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87328612022-01-07 Comparison of Pupil Dilation Responses to Unexpected Sounds in Monkeys and Humans Selezneva, Elena Brosch, Michael Rathi, Sanchit Vighneshvel, T. Wetzel, Nicole Front Psychol Psychology Pupil dilation in response to unexpected stimuli has been well documented in human as well as in non-human primates; however, this phenomenon has not been systematically compared between the species. This analogy is also crucial for the role of non-human primates as an animal model to investigate neural mechanisms underlying the processing of unexpected stimuli and their evoked pupil dilation response. To assess this qualitatively, we used an auditory oddball paradigm in which we presented subjects a sequence of the same sounds followed by occasional deviants while we measured their evoked pupil dilation response (PDR). We used deviants (a frequency deviant, a pink noise burst, a monkey vocalization and a whistle sound) which differed in the spectral composition and in their ability to induce arousal from the standard. Most deviants elicited a significant pupil dilation in both species with decreased peak latency and increased peak amplitude in monkeys compared to humans. A temporal Principal Component Analysis (PCA) revealed two components underlying the PDRs in both species. The early component is likely associated to the parasympathetic nervous system and the late component to the sympathetic nervous system, respectively. Taken together, the present study demonstrates a qualitative similarity between PDRs to unexpected auditory stimuli in macaque and human subjects suggesting that macaques can be a suitable model for investigating the neuronal bases of pupil dilation. However, the quantitative differences in PDRs between species need to be investigated in further comparative studies. Frontiers Media S.A. 2021-12-23 /pmc/articles/PMC8732861/ /pubmed/35002851 http://dx.doi.org/10.3389/fpsyg.2021.754604 Text en Copyright © 2021 Selezneva, Brosch, Rathi, Vighneshvel and Wetzel. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychology Selezneva, Elena Brosch, Michael Rathi, Sanchit Vighneshvel, T. Wetzel, Nicole Comparison of Pupil Dilation Responses to Unexpected Sounds in Monkeys and Humans |
title | Comparison of Pupil Dilation Responses to Unexpected Sounds in Monkeys and Humans |
title_full | Comparison of Pupil Dilation Responses to Unexpected Sounds in Monkeys and Humans |
title_fullStr | Comparison of Pupil Dilation Responses to Unexpected Sounds in Monkeys and Humans |
title_full_unstemmed | Comparison of Pupil Dilation Responses to Unexpected Sounds in Monkeys and Humans |
title_short | Comparison of Pupil Dilation Responses to Unexpected Sounds in Monkeys and Humans |
title_sort | comparison of pupil dilation responses to unexpected sounds in monkeys and humans |
topic | Psychology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732861/ https://www.ncbi.nlm.nih.gov/pubmed/35002851 http://dx.doi.org/10.3389/fpsyg.2021.754604 |
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