Prevalence of mutations in BRCA and homologous recombination repair genes and real-world standard of care of Asian patients with HER2-negative metastatic breast cancer starting first-line systemic cytotoxic chemotherapy: subgroup analysis of the global BREAKOUT study

BACKGROUND: The multinational BREAKOUT study (NCT03078036) sought to determine the prevalence of germline BRCA1/2 (gBRCA1/2) and somatic BRCA1/2 (sBRCA1/2) mutations and mutations in other homologous recombination repair (HRR) genes in women with HER2-negative metastatic breast cancer (MBC) starting...

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Detalles Bibliográficos
Autores principales: Koh, Su-Jin, Ohsumi, Shozo, Takahashi, Masato, Fukuma, Eisuke, Jung, Kyung Hae, Ishida, Takanori, Dai, Ming-Shen, Chang, Chuan-Hsun, Dalvi, Tapashi, Walker, Graham, Bennett, James, O’Shaughnessy, Joyce, Balmaña, Judith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732904/
https://www.ncbi.nlm.nih.gov/pubmed/34467476
http://dx.doi.org/10.1007/s12282-021-01283-4

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