Modifying strategies for SDF-1/CXCR4 interaction during mesenchymal stem cell transplantation

Mesenchymal stem cell (MSC) transplantation is regarded as a promising candidate for the treatment of ischaemic heart disease. The major hurdles for successful clinical translation of MSC therapy are poor survival, retention, and engraftment in the infarcted heart. Stromal cell-derived factor-1/chem...

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Autores principales: Jiang, Qin, Huang, Keli, Lu, Fang, Deng, Shaoping, Yang, Zhenglin, Hu, Shengshou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732940/
https://www.ncbi.nlm.nih.gov/pubmed/34510332
http://dx.doi.org/10.1007/s11748-021-01696-0
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author Jiang, Qin
Huang, Keli
Lu, Fang
Deng, Shaoping
Yang, Zhenglin
Hu, Shengshou
author_facet Jiang, Qin
Huang, Keli
Lu, Fang
Deng, Shaoping
Yang, Zhenglin
Hu, Shengshou
author_sort Jiang, Qin
collection PubMed
description Mesenchymal stem cell (MSC) transplantation is regarded as a promising candidate for the treatment of ischaemic heart disease. The major hurdles for successful clinical translation of MSC therapy are poor survival, retention, and engraftment in the infarcted heart. Stromal cell-derived factor-1/chemokine receptor 4 (SDF-1/CXCR4) constitutes one of the most efficient chemokine/chemokine receptor pairs regarding cell homing. In this review, we mainly focused on previous studies on how to regulate the SDF-1/CXCR4 interaction through various priming strategies to maximize the efficacy of mesenchymal stem cell transplantation on ischaemic hearts or to facilitate the required effects. The strengthened measures for enhancing the therapeutic efficacy of the SDF-1/CXCR4 interaction for mesenchymal stem cell transplantation included the combination of chemokines and cytokines, hormones and drugs, biomaterials, gene engineering, and hypoxia. The priming strategies on recipients for stem cell transplantation included ischaemic conditioning and device techniques.
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spelling pubmed-87329402022-01-18 Modifying strategies for SDF-1/CXCR4 interaction during mesenchymal stem cell transplantation Jiang, Qin Huang, Keli Lu, Fang Deng, Shaoping Yang, Zhenglin Hu, Shengshou Gen Thorac Cardiovasc Surg Review Article Mesenchymal stem cell (MSC) transplantation is regarded as a promising candidate for the treatment of ischaemic heart disease. The major hurdles for successful clinical translation of MSC therapy are poor survival, retention, and engraftment in the infarcted heart. Stromal cell-derived factor-1/chemokine receptor 4 (SDF-1/CXCR4) constitutes one of the most efficient chemokine/chemokine receptor pairs regarding cell homing. In this review, we mainly focused on previous studies on how to regulate the SDF-1/CXCR4 interaction through various priming strategies to maximize the efficacy of mesenchymal stem cell transplantation on ischaemic hearts or to facilitate the required effects. The strengthened measures for enhancing the therapeutic efficacy of the SDF-1/CXCR4 interaction for mesenchymal stem cell transplantation included the combination of chemokines and cytokines, hormones and drugs, biomaterials, gene engineering, and hypoxia. The priming strategies on recipients for stem cell transplantation included ischaemic conditioning and device techniques. Springer Singapore 2021-09-12 2022 /pmc/articles/PMC8732940/ /pubmed/34510332 http://dx.doi.org/10.1007/s11748-021-01696-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Jiang, Qin
Huang, Keli
Lu, Fang
Deng, Shaoping
Yang, Zhenglin
Hu, Shengshou
Modifying strategies for SDF-1/CXCR4 interaction during mesenchymal stem cell transplantation
title Modifying strategies for SDF-1/CXCR4 interaction during mesenchymal stem cell transplantation
title_full Modifying strategies for SDF-1/CXCR4 interaction during mesenchymal stem cell transplantation
title_fullStr Modifying strategies for SDF-1/CXCR4 interaction during mesenchymal stem cell transplantation
title_full_unstemmed Modifying strategies for SDF-1/CXCR4 interaction during mesenchymal stem cell transplantation
title_short Modifying strategies for SDF-1/CXCR4 interaction during mesenchymal stem cell transplantation
title_sort modifying strategies for sdf-1/cxcr4 interaction during mesenchymal stem cell transplantation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732940/
https://www.ncbi.nlm.nih.gov/pubmed/34510332
http://dx.doi.org/10.1007/s11748-021-01696-0
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