Dendrites of Neocortical Pyramidal Neurons: The Key to Understand Intellectual Disability

Pyramidal neurons (PNs) are the most abundant cells of the neocortex and display a vast dendritic tree, divided into basal and apical compartments. Morphological and functional anomalies of PN dendrites are at the basis of virtually all neurological and mental disorders, including intellectual disab...

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Autores principales: Granato, Alberto, Merighi, Adalberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732981/
https://www.ncbi.nlm.nih.gov/pubmed/34216332
http://dx.doi.org/10.1007/s10571-021-01123-1
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author Granato, Alberto
Merighi, Adalberto
author_facet Granato, Alberto
Merighi, Adalberto
author_sort Granato, Alberto
collection PubMed
description Pyramidal neurons (PNs) are the most abundant cells of the neocortex and display a vast dendritic tree, divided into basal and apical compartments. Morphological and functional anomalies of PN dendrites are at the basis of virtually all neurological and mental disorders, including intellectual disability. Here, we provide evidence that the cognitive deficits observed in different types of intellectual disability might be sustained by different parts of the PN dendritic tree, or by a dysregulation of their interaction.
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spelling pubmed-87329812022-01-18 Dendrites of Neocortical Pyramidal Neurons: The Key to Understand Intellectual Disability Granato, Alberto Merighi, Adalberto Cell Mol Neurobiol Article Pyramidal neurons (PNs) are the most abundant cells of the neocortex and display a vast dendritic tree, divided into basal and apical compartments. Morphological and functional anomalies of PN dendrites are at the basis of virtually all neurological and mental disorders, including intellectual disability. Here, we provide evidence that the cognitive deficits observed in different types of intellectual disability might be sustained by different parts of the PN dendritic tree, or by a dysregulation of their interaction. Springer US 2021-07-03 2022 /pmc/articles/PMC8732981/ /pubmed/34216332 http://dx.doi.org/10.1007/s10571-021-01123-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Granato, Alberto
Merighi, Adalberto
Dendrites of Neocortical Pyramidal Neurons: The Key to Understand Intellectual Disability
title Dendrites of Neocortical Pyramidal Neurons: The Key to Understand Intellectual Disability
title_full Dendrites of Neocortical Pyramidal Neurons: The Key to Understand Intellectual Disability
title_fullStr Dendrites of Neocortical Pyramidal Neurons: The Key to Understand Intellectual Disability
title_full_unstemmed Dendrites of Neocortical Pyramidal Neurons: The Key to Understand Intellectual Disability
title_short Dendrites of Neocortical Pyramidal Neurons: The Key to Understand Intellectual Disability
title_sort dendrites of neocortical pyramidal neurons: the key to understand intellectual disability
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732981/
https://www.ncbi.nlm.nih.gov/pubmed/34216332
http://dx.doi.org/10.1007/s10571-021-01123-1
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