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Gene knock-out chain reaction enables high disruption efficiency of HPV18 E6/E7 genes in cervical cancer cells

A genome editing tool targeting the high-risk human papillomavirus (HPV) oncogene is a promising therapeutic strategy to treat HPV-related cervical cancer. To improve gene knockout efficiency, we developed a gene knockout chain reaction (GKCR) method for continually generating mutagenic disruptions...

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Detalles Bibliográficos
Autores principales:	Tian, Rui, Liu, Jiashuo, Fan, Weiwen, Li, Rui, Cui, Zifeng, Jin, Zhuang, Huang, Zhaoyue, Xie, Hongxian, Li, Lifang, Huang, Zheying, Hu, Zheng, Zhou, Ping, Tian, Xun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733033/ https://www.ncbi.nlm.nih.gov/pubmed/35036522 http://dx.doi.org/10.1016/j.omto.2021.12.011

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