Addition of Chk1 inhibitor and BMP4 cooperatively promotes retinal tissue formation in self-organizing human pluripotent stem cell differentiation culture

BACKGROUND: The BMP signaling pathway plays a key role in growth, differentiation and patterning during neural development. Recent work on the generation of a self-organization of three-dimensional retinal organoid (3D-retina) from human pluripotent stem cells (hPSCs) revealed that addition of recom...

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Detalles Bibliográficos
Autores principales: Yamasaki, Suguru, Kuwahara, Atsushi, Kishino, Akiyoshi, Kimura, Toru, Takahashi, Masayo, Mandai, Michiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society for Regenerative Medicine 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733178/
https://www.ncbi.nlm.nih.gov/pubmed/35059477
http://dx.doi.org/10.1016/j.reth.2021.12.003

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