A Genetic modification that reduces ON-bipolar cells in hESC-derived retinas enhances functional integration after transplantation

Pluripotent stem cell (PSC)-derived retinal sheet transplanted in vivo can form structured photoreceptor layers, contact with host bipolar cells, and transmit light signals to host retinas. However, a major concern is the presence of graft bipolar cells that may impede host-graft interaction. In thi...

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Detalles Bibliográficos
Autores principales: Yamasaki, Suguru, Tu, Hung-Ya, Matsuyama, Take, Horiuchi, Matsuri, Hashiguchi, Tomoyo, Sho, Junki, Kuwahara, Atsushi, Kishino, Akiyoshi, Kimura, Toru, Takahashi, Masayo, Mandai, Michiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733179/
https://www.ncbi.nlm.nih.gov/pubmed/35024589
http://dx.doi.org/10.1016/j.isci.2021.103657

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