Molecular and Clinical Significance of Fibroblast Growth Factor 2 in Development and Regeneration of the Auditory System

The fibroblast growth factor 2 (FGF2) is a member of the FGF family which is involved in key biological processes including development, cellular proliferation, wound healing, and angiogenesis. Although the utility of the FGF family as therapeutic agents has attracted attention, and FGF2 has been st...

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Autores principales: Jeong, Minjin, Bojkovic, Katarina, Sagi, Varun, Stankovic, Konstantina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733209/
https://www.ncbi.nlm.nih.gov/pubmed/35002617
http://dx.doi.org/10.3389/fnmol.2021.757441
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author Jeong, Minjin
Bojkovic, Katarina
Sagi, Varun
Stankovic, Konstantina M.
author_facet Jeong, Minjin
Bojkovic, Katarina
Sagi, Varun
Stankovic, Konstantina M.
author_sort Jeong, Minjin
collection PubMed
description The fibroblast growth factor 2 (FGF2) is a member of the FGF family which is involved in key biological processes including development, cellular proliferation, wound healing, and angiogenesis. Although the utility of the FGF family as therapeutic agents has attracted attention, and FGF2 has been studied in several clinical contexts, there remains an incomplete understanding of the molecular and clinical function of FGF2 in the auditory system. In this review, we highlight the role of FGF2 in inner ear development and hearing protection and present relevant clinical studies for tympanic membrane (TM) repair. We conclude by discussing the future implications of FGF2 as a potential therapeutic agent.
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spelling pubmed-87332092022-01-07 Molecular and Clinical Significance of Fibroblast Growth Factor 2 in Development and Regeneration of the Auditory System Jeong, Minjin Bojkovic, Katarina Sagi, Varun Stankovic, Konstantina M. Front Mol Neurosci Molecular Neuroscience The fibroblast growth factor 2 (FGF2) is a member of the FGF family which is involved in key biological processes including development, cellular proliferation, wound healing, and angiogenesis. Although the utility of the FGF family as therapeutic agents has attracted attention, and FGF2 has been studied in several clinical contexts, there remains an incomplete understanding of the molecular and clinical function of FGF2 in the auditory system. In this review, we highlight the role of FGF2 in inner ear development and hearing protection and present relevant clinical studies for tympanic membrane (TM) repair. We conclude by discussing the future implications of FGF2 as a potential therapeutic agent. Frontiers Media S.A. 2021-12-23 /pmc/articles/PMC8733209/ /pubmed/35002617 http://dx.doi.org/10.3389/fnmol.2021.757441 Text en Copyright © 2021 Jeong, Bojkovic, Sagi and Stankovic. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Neuroscience
Jeong, Minjin
Bojkovic, Katarina
Sagi, Varun
Stankovic, Konstantina M.
Molecular and Clinical Significance of Fibroblast Growth Factor 2 in Development and Regeneration of the Auditory System
title Molecular and Clinical Significance of Fibroblast Growth Factor 2 in Development and Regeneration of the Auditory System
title_full Molecular and Clinical Significance of Fibroblast Growth Factor 2 in Development and Regeneration of the Auditory System
title_fullStr Molecular and Clinical Significance of Fibroblast Growth Factor 2 in Development and Regeneration of the Auditory System
title_full_unstemmed Molecular and Clinical Significance of Fibroblast Growth Factor 2 in Development and Regeneration of the Auditory System
title_short Molecular and Clinical Significance of Fibroblast Growth Factor 2 in Development and Regeneration of the Auditory System
title_sort molecular and clinical significance of fibroblast growth factor 2 in development and regeneration of the auditory system
topic Molecular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733209/
https://www.ncbi.nlm.nih.gov/pubmed/35002617
http://dx.doi.org/10.3389/fnmol.2021.757441
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