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A Whole-Brain Connectivity Map of VTA and SNc Glutamatergic and GABAergic Neurons in Mice
The glutamatergic and GABAergic neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) mediated diverse brain functions. However, their whole-brain neural connectivity has not been comprehensively mapped. Here we used the virus tracers to characterize the whole-brain in...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733212/ https://www.ncbi.nlm.nih.gov/pubmed/35002641 http://dx.doi.org/10.3389/fnana.2021.818242 |
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author | An, Sile Li, Xiangning Deng, Lei Zhao, Peilin Ding, Zhangheng Han, Yutong Luo, Yue Liu, Xin Li, Anan Luo, Qingming Feng, Zhao Gong, Hui |
author_facet | An, Sile Li, Xiangning Deng, Lei Zhao, Peilin Ding, Zhangheng Han, Yutong Luo, Yue Liu, Xin Li, Anan Luo, Qingming Feng, Zhao Gong, Hui |
author_sort | An, Sile |
collection | PubMed |
description | The glutamatergic and GABAergic neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) mediated diverse brain functions. However, their whole-brain neural connectivity has not been comprehensively mapped. Here we used the virus tracers to characterize the whole-brain inputs and outputs of glutamatergic and GABAergic neurons in VTA and SNc. We found that these neurons received similar inputs from upstream brain regions, but some quantitative differences were also observed. Neocortex and dorsal striatum provided a greater share of input to VTA glutamatergic neurons. Periaqueductal gray and lateral hypothalamic area preferentially innervated VTA GABAergic neurons. Specifically, superior colliculus provided the largest input to SNc glutamatergic neurons. Compared to input patterns, the output patterns of glutamatergic and GABAergic neurons in the VTA and SNc showed significant preference to different brain regions. Our results laid the anatomical foundation for understanding the functions of cell-type-specific neurons in VTA and SNc. |
format | Online Article Text |
id | pubmed-8733212 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87332122022-01-07 A Whole-Brain Connectivity Map of VTA and SNc Glutamatergic and GABAergic Neurons in Mice An, Sile Li, Xiangning Deng, Lei Zhao, Peilin Ding, Zhangheng Han, Yutong Luo, Yue Liu, Xin Li, Anan Luo, Qingming Feng, Zhao Gong, Hui Front Neuroanat Neuroanatomy The glutamatergic and GABAergic neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) mediated diverse brain functions. However, their whole-brain neural connectivity has not been comprehensively mapped. Here we used the virus tracers to characterize the whole-brain inputs and outputs of glutamatergic and GABAergic neurons in VTA and SNc. We found that these neurons received similar inputs from upstream brain regions, but some quantitative differences were also observed. Neocortex and dorsal striatum provided a greater share of input to VTA glutamatergic neurons. Periaqueductal gray and lateral hypothalamic area preferentially innervated VTA GABAergic neurons. Specifically, superior colliculus provided the largest input to SNc glutamatergic neurons. Compared to input patterns, the output patterns of glutamatergic and GABAergic neurons in the VTA and SNc showed significant preference to different brain regions. Our results laid the anatomical foundation for understanding the functions of cell-type-specific neurons in VTA and SNc. Frontiers Media S.A. 2021-12-23 /pmc/articles/PMC8733212/ /pubmed/35002641 http://dx.doi.org/10.3389/fnana.2021.818242 Text en Copyright © 2021 An, Li, Deng, Zhao, Ding, Han, Luo, Liu, Li, Luo, Feng and Gong. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroanatomy An, Sile Li, Xiangning Deng, Lei Zhao, Peilin Ding, Zhangheng Han, Yutong Luo, Yue Liu, Xin Li, Anan Luo, Qingming Feng, Zhao Gong, Hui A Whole-Brain Connectivity Map of VTA and SNc Glutamatergic and GABAergic Neurons in Mice |
title | A Whole-Brain Connectivity Map of VTA and SNc Glutamatergic and GABAergic Neurons in Mice |
title_full | A Whole-Brain Connectivity Map of VTA and SNc Glutamatergic and GABAergic Neurons in Mice |
title_fullStr | A Whole-Brain Connectivity Map of VTA and SNc Glutamatergic and GABAergic Neurons in Mice |
title_full_unstemmed | A Whole-Brain Connectivity Map of VTA and SNc Glutamatergic and GABAergic Neurons in Mice |
title_short | A Whole-Brain Connectivity Map of VTA and SNc Glutamatergic and GABAergic Neurons in Mice |
title_sort | whole-brain connectivity map of vta and snc glutamatergic and gabaergic neurons in mice |
topic | Neuroanatomy |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733212/ https://www.ncbi.nlm.nih.gov/pubmed/35002641 http://dx.doi.org/10.3389/fnana.2021.818242 |
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