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Cryo-EM of the ATP11C flippase reconstituted in Nanodiscs shows a distended phospholipid bilayer inner membrane around transmembrane helix 2

ATP11C is a member of the P4-ATPase flippase family that mediates translocation of phosphatidylserine (PtdSer) across the lipid bilayer. In order to characterize the structure and function of ATP11C in a model natural lipid environment, we revisited and optimized a quick procedure for reconstituting...

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Detalles Bibliográficos
Autores principales:	Nakanishi, Hanayo, Hayashida, Kenichi, Nishizawa, Tomohiro, Oshima, Atsunori, Abe, Kazuhiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733269/ https://www.ncbi.nlm.nih.gov/pubmed/34922944 http://dx.doi.org/10.1016/j.jbc.2021.101498

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