Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces and prevents pain chronification in a mouse model of oxaliplatin-induced neuropathic pain

Treatment with anti-neoplastic agents can lead to the development of chemotherapy induced peripheral neuropathy (CIPN), which is long lasting and often refractory to treatment. This neuropathic pain develops along dermatomes innervated by peripheral nerves with cell bodies located in the dorsal root...

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Detalles Bibliográficos
Autores principales: Braden, Kathryn, Stratton, Harrison J., Salvemini, Daniela, Khanna, Rajesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733339/
https://www.ncbi.nlm.nih.gov/pubmed/35024498
http://dx.doi.org/10.1016/j.ynpai.2021.100082

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