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Unraveling the Gordian knot: genetics and the troubled road to effective therapeutics for Alzheimer’s disease
In the late 20th century, identification of the major protein components of amyloid plaques and neurofibrillary tangles provided a window into the molecular pathology of Alzheimer’s disease, ushering in an era of optimism that targeted therapeutics would soon follow. The amyloid-cascade hypothesis t...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733445/ https://www.ncbi.nlm.nih.gov/pubmed/34718566 http://dx.doi.org/10.1093/genetics/iyab185 |