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Population-Based Prevalence of Ocular Chlamydia trachomatis Infection among Infants in the Trachoma Endemic Amhara Region, Ethiopia

Infants ages < 6 months do not receive azithromycin as part of trachoma control and thus may serve as an infection reservoir in persistently endemic districts. The aim of this study was to determine the population-based Chlamydia trachomatis infection prevalence and infectious load among infants...

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Autores principales: Nash, Scott D., Chernet, Ambahun, Astale, Tigist, Sata, Eshetu, Zerihun, Mulat, Nute, Andrew W., Jensen, Kimberly A., Gessese, Demelash, Ayele, Zebene, Melak, Berhanu, Haile, Mahteme, Zeru, Taye, Tadesse, Zerihun, Kelly Callahan, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733485/
https://www.ncbi.nlm.nih.gov/pubmed/34695789
http://dx.doi.org/10.4269/ajtmh.21-0873
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author Nash, Scott D.
Chernet, Ambahun
Astale, Tigist
Sata, Eshetu
Zerihun, Mulat
Nute, Andrew W.
Jensen, Kimberly A.
Gessese, Demelash
Ayele, Zebene
Melak, Berhanu
Haile, Mahteme
Zeru, Taye
Tadesse, Zerihun
Kelly Callahan, E.
author_facet Nash, Scott D.
Chernet, Ambahun
Astale, Tigist
Sata, Eshetu
Zerihun, Mulat
Nute, Andrew W.
Jensen, Kimberly A.
Gessese, Demelash
Ayele, Zebene
Melak, Berhanu
Haile, Mahteme
Zeru, Taye
Tadesse, Zerihun
Kelly Callahan, E.
author_sort Nash, Scott D.
collection PubMed
description Infants ages < 6 months do not receive azithromycin as part of trachoma control and thus may serve as an infection reservoir in persistently endemic districts. The aim of this study was to determine the population-based Chlamydia trachomatis infection prevalence and infectious load among infants ages 1–12 months in persistently trachoma endemic districts in Amhara, Ethiopia. Across six districts, 475 infants were enumerated, and of these 464 (97.7%) were swabbed for infection testing. The C. trachomatis infection prevalence in the study area among infants was 0.2% (95% CI: 0.0–1.5). Among children ages 0–5 years positive for C. trachomatis, the median load was 31 elementary bodies (EB) (Inter quartile range: 7–244 EB), and the infection-positive infant had a load of 7,755 EB. While it is worth reconsidering azithromycin treatment recommendations for the potential mortality benefits, these results do not support lowering the treatment age for trachoma control.
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spelling pubmed-87334852022-01-21 Population-Based Prevalence of Ocular Chlamydia trachomatis Infection among Infants in the Trachoma Endemic Amhara Region, Ethiopia Nash, Scott D. Chernet, Ambahun Astale, Tigist Sata, Eshetu Zerihun, Mulat Nute, Andrew W. Jensen, Kimberly A. Gessese, Demelash Ayele, Zebene Melak, Berhanu Haile, Mahteme Zeru, Taye Tadesse, Zerihun Kelly Callahan, E. Am J Trop Med Hyg Article Infants ages < 6 months do not receive azithromycin as part of trachoma control and thus may serve as an infection reservoir in persistently endemic districts. The aim of this study was to determine the population-based Chlamydia trachomatis infection prevalence and infectious load among infants ages 1–12 months in persistently trachoma endemic districts in Amhara, Ethiopia. Across six districts, 475 infants were enumerated, and of these 464 (97.7%) were swabbed for infection testing. The C. trachomatis infection prevalence in the study area among infants was 0.2% (95% CI: 0.0–1.5). Among children ages 0–5 years positive for C. trachomatis, the median load was 31 elementary bodies (EB) (Inter quartile range: 7–244 EB), and the infection-positive infant had a load of 7,755 EB. While it is worth reconsidering azithromycin treatment recommendations for the potential mortality benefits, these results do not support lowering the treatment age for trachoma control. The American Society of Tropical Medicine and Hygiene 2022-01 2021-10-25 /pmc/articles/PMC8733485/ /pubmed/34695789 http://dx.doi.org/10.4269/ajtmh.21-0873 Text en © 2022 by The American Society of Tropical Medicine and Hygiene https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Nash, Scott D.
Chernet, Ambahun
Astale, Tigist
Sata, Eshetu
Zerihun, Mulat
Nute, Andrew W.
Jensen, Kimberly A.
Gessese, Demelash
Ayele, Zebene
Melak, Berhanu
Haile, Mahteme
Zeru, Taye
Tadesse, Zerihun
Kelly Callahan, E.
Population-Based Prevalence of Ocular Chlamydia trachomatis Infection among Infants in the Trachoma Endemic Amhara Region, Ethiopia
title Population-Based Prevalence of Ocular Chlamydia trachomatis Infection among Infants in the Trachoma Endemic Amhara Region, Ethiopia
title_full Population-Based Prevalence of Ocular Chlamydia trachomatis Infection among Infants in the Trachoma Endemic Amhara Region, Ethiopia
title_fullStr Population-Based Prevalence of Ocular Chlamydia trachomatis Infection among Infants in the Trachoma Endemic Amhara Region, Ethiopia
title_full_unstemmed Population-Based Prevalence of Ocular Chlamydia trachomatis Infection among Infants in the Trachoma Endemic Amhara Region, Ethiopia
title_short Population-Based Prevalence of Ocular Chlamydia trachomatis Infection among Infants in the Trachoma Endemic Amhara Region, Ethiopia
title_sort population-based prevalence of ocular chlamydia trachomatis infection among infants in the trachoma endemic amhara region, ethiopia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733485/
https://www.ncbi.nlm.nih.gov/pubmed/34695789
http://dx.doi.org/10.4269/ajtmh.21-0873
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