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Properties, Structures, and Physiological Roles of Three Types of Anion Channels Molecularly Identified in the 2010’s
Molecular identification was, at last, successfully accomplished for three types of anion channels that are all implicated in cell volume regulation/dysregulation. LRRC8A plus LRRC8C/D/E, SLCO2A1, and TMEM206 were shown to be the core or pore-forming molecules of the volume-sensitive outwardly recti...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733619/ https://www.ncbi.nlm.nih.gov/pubmed/35002778 http://dx.doi.org/10.3389/fphys.2021.805148 |
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author | Okada, Yasunobu Sabirov, Ravshan Z. Merzlyak, Petr G. Numata, Tomohiro Sato-Numata, Kaori |
author_facet | Okada, Yasunobu Sabirov, Ravshan Z. Merzlyak, Petr G. Numata, Tomohiro Sato-Numata, Kaori |
author_sort | Okada, Yasunobu |
collection | PubMed |
description | Molecular identification was, at last, successfully accomplished for three types of anion channels that are all implicated in cell volume regulation/dysregulation. LRRC8A plus LRRC8C/D/E, SLCO2A1, and TMEM206 were shown to be the core or pore-forming molecules of the volume-sensitive outwardly rectifying anion channel (VSOR) also called the volume-regulated anion channel (VRAC), the large-conductance maxi-anion channel (Maxi-Cl), and the acid-sensitive outwardly rectifying anion channel (ASOR) also called the proton-activated anion channel (PAC) in 2014, 2017, and 2019, respectively. More recently in 2020 and 2021, we have identified the S100A10-annexin A2 complex and TRPM7 as the regulatory proteins for Maxi-Cl and VSOR/VRAC, respectively. In this review article, we summarize their biophysical and structural properties as well as their physiological roles by comparing with each other on the basis of their molecular insights. We also point out unsolved important issues to be elucidated soon in the future. |
format | Online Article Text |
id | pubmed-8733619 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87336192022-01-07 Properties, Structures, and Physiological Roles of Three Types of Anion Channels Molecularly Identified in the 2010’s Okada, Yasunobu Sabirov, Ravshan Z. Merzlyak, Petr G. Numata, Tomohiro Sato-Numata, Kaori Front Physiol Physiology Molecular identification was, at last, successfully accomplished for three types of anion channels that are all implicated in cell volume regulation/dysregulation. LRRC8A plus LRRC8C/D/E, SLCO2A1, and TMEM206 were shown to be the core or pore-forming molecules of the volume-sensitive outwardly rectifying anion channel (VSOR) also called the volume-regulated anion channel (VRAC), the large-conductance maxi-anion channel (Maxi-Cl), and the acid-sensitive outwardly rectifying anion channel (ASOR) also called the proton-activated anion channel (PAC) in 2014, 2017, and 2019, respectively. More recently in 2020 and 2021, we have identified the S100A10-annexin A2 complex and TRPM7 as the regulatory proteins for Maxi-Cl and VSOR/VRAC, respectively. In this review article, we summarize their biophysical and structural properties as well as their physiological roles by comparing with each other on the basis of their molecular insights. We also point out unsolved important issues to be elucidated soon in the future. Frontiers Media S.A. 2021-12-23 /pmc/articles/PMC8733619/ /pubmed/35002778 http://dx.doi.org/10.3389/fphys.2021.805148 Text en Copyright © 2021 Okada, Sabirov, Merzlyak, Numata and Sato-Numata. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Okada, Yasunobu Sabirov, Ravshan Z. Merzlyak, Petr G. Numata, Tomohiro Sato-Numata, Kaori Properties, Structures, and Physiological Roles of Three Types of Anion Channels Molecularly Identified in the 2010’s |
title | Properties, Structures, and Physiological Roles of Three Types of Anion Channels Molecularly Identified in the 2010’s |
title_full | Properties, Structures, and Physiological Roles of Three Types of Anion Channels Molecularly Identified in the 2010’s |
title_fullStr | Properties, Structures, and Physiological Roles of Three Types of Anion Channels Molecularly Identified in the 2010’s |
title_full_unstemmed | Properties, Structures, and Physiological Roles of Three Types of Anion Channels Molecularly Identified in the 2010’s |
title_short | Properties, Structures, and Physiological Roles of Three Types of Anion Channels Molecularly Identified in the 2010’s |
title_sort | properties, structures, and physiological roles of three types of anion channels molecularly identified in the 2010’s |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733619/ https://www.ncbi.nlm.nih.gov/pubmed/35002778 http://dx.doi.org/10.3389/fphys.2021.805148 |
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