Cargando…

Properties, Structures, and Physiological Roles of Three Types of Anion Channels Molecularly Identified in the 2010’s

Molecular identification was, at last, successfully accomplished for three types of anion channels that are all implicated in cell volume regulation/dysregulation. LRRC8A plus LRRC8C/D/E, SLCO2A1, and TMEM206 were shown to be the core or pore-forming molecules of the volume-sensitive outwardly recti...

Descripción completa

Detalles Bibliográficos
Autores principales: Okada, Yasunobu, Sabirov, Ravshan Z., Merzlyak, Petr G., Numata, Tomohiro, Sato-Numata, Kaori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733619/
https://www.ncbi.nlm.nih.gov/pubmed/35002778
http://dx.doi.org/10.3389/fphys.2021.805148
_version_ 1784627837924278272
author Okada, Yasunobu
Sabirov, Ravshan Z.
Merzlyak, Petr G.
Numata, Tomohiro
Sato-Numata, Kaori
author_facet Okada, Yasunobu
Sabirov, Ravshan Z.
Merzlyak, Petr G.
Numata, Tomohiro
Sato-Numata, Kaori
author_sort Okada, Yasunobu
collection PubMed
description Molecular identification was, at last, successfully accomplished for three types of anion channels that are all implicated in cell volume regulation/dysregulation. LRRC8A plus LRRC8C/D/E, SLCO2A1, and TMEM206 were shown to be the core or pore-forming molecules of the volume-sensitive outwardly rectifying anion channel (VSOR) also called the volume-regulated anion channel (VRAC), the large-conductance maxi-anion channel (Maxi-Cl), and the acid-sensitive outwardly rectifying anion channel (ASOR) also called the proton-activated anion channel (PAC) in 2014, 2017, and 2019, respectively. More recently in 2020 and 2021, we have identified the S100A10-annexin A2 complex and TRPM7 as the regulatory proteins for Maxi-Cl and VSOR/VRAC, respectively. In this review article, we summarize their biophysical and structural properties as well as their physiological roles by comparing with each other on the basis of their molecular insights. We also point out unsolved important issues to be elucidated soon in the future.
format Online
Article
Text
id pubmed-8733619
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-87336192022-01-07 Properties, Structures, and Physiological Roles of Three Types of Anion Channels Molecularly Identified in the 2010’s Okada, Yasunobu Sabirov, Ravshan Z. Merzlyak, Petr G. Numata, Tomohiro Sato-Numata, Kaori Front Physiol Physiology Molecular identification was, at last, successfully accomplished for three types of anion channels that are all implicated in cell volume regulation/dysregulation. LRRC8A plus LRRC8C/D/E, SLCO2A1, and TMEM206 were shown to be the core or pore-forming molecules of the volume-sensitive outwardly rectifying anion channel (VSOR) also called the volume-regulated anion channel (VRAC), the large-conductance maxi-anion channel (Maxi-Cl), and the acid-sensitive outwardly rectifying anion channel (ASOR) also called the proton-activated anion channel (PAC) in 2014, 2017, and 2019, respectively. More recently in 2020 and 2021, we have identified the S100A10-annexin A2 complex and TRPM7 as the regulatory proteins for Maxi-Cl and VSOR/VRAC, respectively. In this review article, we summarize their biophysical and structural properties as well as their physiological roles by comparing with each other on the basis of their molecular insights. We also point out unsolved important issues to be elucidated soon in the future. Frontiers Media S.A. 2021-12-23 /pmc/articles/PMC8733619/ /pubmed/35002778 http://dx.doi.org/10.3389/fphys.2021.805148 Text en Copyright © 2021 Okada, Sabirov, Merzlyak, Numata and Sato-Numata. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Okada, Yasunobu
Sabirov, Ravshan Z.
Merzlyak, Petr G.
Numata, Tomohiro
Sato-Numata, Kaori
Properties, Structures, and Physiological Roles of Three Types of Anion Channels Molecularly Identified in the 2010’s
title Properties, Structures, and Physiological Roles of Three Types of Anion Channels Molecularly Identified in the 2010’s
title_full Properties, Structures, and Physiological Roles of Three Types of Anion Channels Molecularly Identified in the 2010’s
title_fullStr Properties, Structures, and Physiological Roles of Three Types of Anion Channels Molecularly Identified in the 2010’s
title_full_unstemmed Properties, Structures, and Physiological Roles of Three Types of Anion Channels Molecularly Identified in the 2010’s
title_short Properties, Structures, and Physiological Roles of Three Types of Anion Channels Molecularly Identified in the 2010’s
title_sort properties, structures, and physiological roles of three types of anion channels molecularly identified in the 2010’s
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733619/
https://www.ncbi.nlm.nih.gov/pubmed/35002778
http://dx.doi.org/10.3389/fphys.2021.805148
work_keys_str_mv AT okadayasunobu propertiesstructuresandphysiologicalrolesofthreetypesofanionchannelsmolecularlyidentifiedinthe2010s
AT sabirovravshanz propertiesstructuresandphysiologicalrolesofthreetypesofanionchannelsmolecularlyidentifiedinthe2010s
AT merzlyakpetrg propertiesstructuresandphysiologicalrolesofthreetypesofanionchannelsmolecularlyidentifiedinthe2010s
AT numatatomohiro propertiesstructuresandphysiologicalrolesofthreetypesofanionchannelsmolecularlyidentifiedinthe2010s
AT satonumatakaori propertiesstructuresandphysiologicalrolesofthreetypesofanionchannelsmolecularlyidentifiedinthe2010s