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The Chest Radiographic Thoracic Area Can Serve as a Prediction Marker for Morbidity and Mortality in Infants With Congenital Diaphragmatic Hernia

Objective: Valid postnatal prediction parameters for neonates with congenital diaphragmatic hernia (CDH) are lacking, but recently, the chest radiographic thoracic area (CRTA) was proposed to predict survival with high sensitivity. Here, we evaluated whether the CRTA correlated with morbidity and mo...

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Autores principales: Weis, Meike, Burhany, Sosan, Perez Ortiz, Alba, Nowak, Oliver, Hetjens, Svetlana, Zahn, Katrin, Schoenberg, Stefan, Schaible, Thomas, Rafat, Neysan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733701/
https://www.ncbi.nlm.nih.gov/pubmed/35004536
http://dx.doi.org/10.3389/fped.2021.740941
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author Weis, Meike
Burhany, Sosan
Perez Ortiz, Alba
Nowak, Oliver
Hetjens, Svetlana
Zahn, Katrin
Schoenberg, Stefan
Schaible, Thomas
Rafat, Neysan
author_facet Weis, Meike
Burhany, Sosan
Perez Ortiz, Alba
Nowak, Oliver
Hetjens, Svetlana
Zahn, Katrin
Schoenberg, Stefan
Schaible, Thomas
Rafat, Neysan
author_sort Weis, Meike
collection PubMed
description Objective: Valid postnatal prediction parameters for neonates with congenital diaphragmatic hernia (CDH) are lacking, but recently, the chest radiographic thoracic area (CRTA) was proposed to predict survival with high sensitivity. Here, we evaluated whether the CRTA correlated with morbidity and mortality in neonates with CDH and was able to predict these with higher sensitivity and specificity than prenatal observed-to-expected (O/E) lung-to-head ratio (LHR). Methods: In this retrospective cohort study, all neonates with CDH admitted to our institution between 2013 and 2019 were included. The CRTA was measured using the software Horos (V. 3.3.5) and compared with O/E LHR diagnosed by fetal ultrasonography in relation to outcome parameters including survival, extracorporeal membrane oxygenation (ECMO) support, and chronic lung disease (CLD). Results: In this study 255 neonates were included with a survival to discharge of 84%, ECMO support in 46%, and 56% developing a CLD. Multiple regression analysis demonstrated that the CRTA correlates significantly with survival (p = 0.001), ECMO support (p < 0.0001), and development of CLD (p = 0.0193). The CRTA displayed a higher prognostic validity for survival [area under the curve (AUC) = 0.822], ECMO support (AUC = 0.802), and developing a CLD (AUC = 0.855) compared with the O/E LHR. Conclusions: Our data suggest that the postnatal CRTA might be a better prognostic parameter for morbidity and mortality than the prenatal O/E LHR.
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spelling pubmed-87337012022-01-07 The Chest Radiographic Thoracic Area Can Serve as a Prediction Marker for Morbidity and Mortality in Infants With Congenital Diaphragmatic Hernia Weis, Meike Burhany, Sosan Perez Ortiz, Alba Nowak, Oliver Hetjens, Svetlana Zahn, Katrin Schoenberg, Stefan Schaible, Thomas Rafat, Neysan Front Pediatr Pediatrics Objective: Valid postnatal prediction parameters for neonates with congenital diaphragmatic hernia (CDH) are lacking, but recently, the chest radiographic thoracic area (CRTA) was proposed to predict survival with high sensitivity. Here, we evaluated whether the CRTA correlated with morbidity and mortality in neonates with CDH and was able to predict these with higher sensitivity and specificity than prenatal observed-to-expected (O/E) lung-to-head ratio (LHR). Methods: In this retrospective cohort study, all neonates with CDH admitted to our institution between 2013 and 2019 were included. The CRTA was measured using the software Horos (V. 3.3.5) and compared with O/E LHR diagnosed by fetal ultrasonography in relation to outcome parameters including survival, extracorporeal membrane oxygenation (ECMO) support, and chronic lung disease (CLD). Results: In this study 255 neonates were included with a survival to discharge of 84%, ECMO support in 46%, and 56% developing a CLD. Multiple regression analysis demonstrated that the CRTA correlates significantly with survival (p = 0.001), ECMO support (p < 0.0001), and development of CLD (p = 0.0193). The CRTA displayed a higher prognostic validity for survival [area under the curve (AUC) = 0.822], ECMO support (AUC = 0.802), and developing a CLD (AUC = 0.855) compared with the O/E LHR. Conclusions: Our data suggest that the postnatal CRTA might be a better prognostic parameter for morbidity and mortality than the prenatal O/E LHR. Frontiers Media S.A. 2021-12-23 /pmc/articles/PMC8733701/ /pubmed/35004536 http://dx.doi.org/10.3389/fped.2021.740941 Text en Copyright © 2021 Weis, Burhany, Perez Ortiz, Nowak, Hetjens, Zahn, Schoenberg, Schaible and Rafat. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Weis, Meike
Burhany, Sosan
Perez Ortiz, Alba
Nowak, Oliver
Hetjens, Svetlana
Zahn, Katrin
Schoenberg, Stefan
Schaible, Thomas
Rafat, Neysan
The Chest Radiographic Thoracic Area Can Serve as a Prediction Marker for Morbidity and Mortality in Infants With Congenital Diaphragmatic Hernia
title The Chest Radiographic Thoracic Area Can Serve as a Prediction Marker for Morbidity and Mortality in Infants With Congenital Diaphragmatic Hernia
title_full The Chest Radiographic Thoracic Area Can Serve as a Prediction Marker for Morbidity and Mortality in Infants With Congenital Diaphragmatic Hernia
title_fullStr The Chest Radiographic Thoracic Area Can Serve as a Prediction Marker for Morbidity and Mortality in Infants With Congenital Diaphragmatic Hernia
title_full_unstemmed The Chest Radiographic Thoracic Area Can Serve as a Prediction Marker for Morbidity and Mortality in Infants With Congenital Diaphragmatic Hernia
title_short The Chest Radiographic Thoracic Area Can Serve as a Prediction Marker for Morbidity and Mortality in Infants With Congenital Diaphragmatic Hernia
title_sort chest radiographic thoracic area can serve as a prediction marker for morbidity and mortality in infants with congenital diaphragmatic hernia
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733701/
https://www.ncbi.nlm.nih.gov/pubmed/35004536
http://dx.doi.org/10.3389/fped.2021.740941
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