Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling and Intensified Design of Experiments

Reliable process development is accompanied by intense experimental effort. The utilization of an intensified design of experiments (iDoE) (intra-experimental critical process parameter (CPP) shifts combined) with hybrid modeling potentially reduces process development burden. The iDoE can provide m...

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Detalles Bibliográficos
Autores principales: Bayer, Benjamin, Duerkop, Mark, Striedner, Gerald, Sissolak, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733703/
https://www.ncbi.nlm.nih.gov/pubmed/35004635
http://dx.doi.org/10.3389/fbioe.2021.740215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733703/
https://www.ncbi.nlm.nih.gov/pubmed/35004635
http://dx.doi.org/10.3389/fbioe.2021.740215

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