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Host Factor Interaction Networks Identified by Integrative Bioinformatics Analysis Reveals Therapeutic Implications in COPD Patients With COVID-19

Background: The COVID-19 pandemic poses an imminent threat to humanity, especially for those who have comorbidities. Evidence of COVID-19 and COPD comorbidities is accumulating. However, data revealing the molecular mechanism of COVID-19 and COPD comorbid diseases is limited. Methods: We got COVID-1...

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Autores principales: Zheng, Wenjiang, Wang, Ting, Wu, Peng, Yan, Qian, Liu, Chengxin, Wu, Hui, Zhan, Shaofeng, Liu, Xiaohong, Jiang, Yong, Zhuang, Hongfa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733735/
https://www.ncbi.nlm.nih.gov/pubmed/35002688
http://dx.doi.org/10.3389/fphar.2021.718874
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author Zheng, Wenjiang
Wang, Ting
Wu, Peng
Yan, Qian
Liu, Chengxin
Wu, Hui
Zhan, Shaofeng
Liu, Xiaohong
Jiang, Yong
Zhuang, Hongfa
author_facet Zheng, Wenjiang
Wang, Ting
Wu, Peng
Yan, Qian
Liu, Chengxin
Wu, Hui
Zhan, Shaofeng
Liu, Xiaohong
Jiang, Yong
Zhuang, Hongfa
author_sort Zheng, Wenjiang
collection PubMed
description Background: The COVID-19 pandemic poses an imminent threat to humanity, especially for those who have comorbidities. Evidence of COVID-19 and COPD comorbidities is accumulating. However, data revealing the molecular mechanism of COVID-19 and COPD comorbid diseases is limited. Methods: We got COVID-19/COPD -related genes from different databases by restricted screening conditions (top500), respectively, and then supplemented with COVID-19/COPD-associated genes (FDR<0.05, |LogFC|≥1) from clinical sample data sets. By taking the intersection, 42 co-morbid host factors for COVID-19 and COPD were finally obtained. On the basis of shared host factors, we conducted a series of bioinformatics analysis, including protein-protein interaction analysis, gene ontology and pathway enrichment analysis, transcription factor-gene interaction network analysis, gene-microRNA co-regulatory network analysis, tissue-specific enrichment analysis and candidate drug prediction. Results: We revealed the comorbidity mechanism of COVID-19 and COPD from the perspective of host factor interaction, obtained the top ten gene and 3 modules with different biological functions. Furthermore, we have obtained the signaling pathways and concluded that dexamethasone, estradiol, progesterone, and nitric oxide shows effective interventions. Conclusion: This study revealed host factor interaction networks for COVID-19 and COPD, which could confirm the potential drugs for treating the comorbidity, ultimately, enhancing the management of the respiratory disease.
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spelling pubmed-87337352022-01-07 Host Factor Interaction Networks Identified by Integrative Bioinformatics Analysis Reveals Therapeutic Implications in COPD Patients With COVID-19 Zheng, Wenjiang Wang, Ting Wu, Peng Yan, Qian Liu, Chengxin Wu, Hui Zhan, Shaofeng Liu, Xiaohong Jiang, Yong Zhuang, Hongfa Front Pharmacol Pharmacology Background: The COVID-19 pandemic poses an imminent threat to humanity, especially for those who have comorbidities. Evidence of COVID-19 and COPD comorbidities is accumulating. However, data revealing the molecular mechanism of COVID-19 and COPD comorbid diseases is limited. Methods: We got COVID-19/COPD -related genes from different databases by restricted screening conditions (top500), respectively, and then supplemented with COVID-19/COPD-associated genes (FDR<0.05, |LogFC|≥1) from clinical sample data sets. By taking the intersection, 42 co-morbid host factors for COVID-19 and COPD were finally obtained. On the basis of shared host factors, we conducted a series of bioinformatics analysis, including protein-protein interaction analysis, gene ontology and pathway enrichment analysis, transcription factor-gene interaction network analysis, gene-microRNA co-regulatory network analysis, tissue-specific enrichment analysis and candidate drug prediction. Results: We revealed the comorbidity mechanism of COVID-19 and COPD from the perspective of host factor interaction, obtained the top ten gene and 3 modules with different biological functions. Furthermore, we have obtained the signaling pathways and concluded that dexamethasone, estradiol, progesterone, and nitric oxide shows effective interventions. Conclusion: This study revealed host factor interaction networks for COVID-19 and COPD, which could confirm the potential drugs for treating the comorbidity, ultimately, enhancing the management of the respiratory disease. Frontiers Media S.A. 2021-12-23 /pmc/articles/PMC8733735/ /pubmed/35002688 http://dx.doi.org/10.3389/fphar.2021.718874 Text en Copyright © 2021 Zheng, Wang, Wu, Yan, Liu, Wu, Zhan, Liu, Jiang and Zhuang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Zheng, Wenjiang
Wang, Ting
Wu, Peng
Yan, Qian
Liu, Chengxin
Wu, Hui
Zhan, Shaofeng
Liu, Xiaohong
Jiang, Yong
Zhuang, Hongfa
Host Factor Interaction Networks Identified by Integrative Bioinformatics Analysis Reveals Therapeutic Implications in COPD Patients With COVID-19
title Host Factor Interaction Networks Identified by Integrative Bioinformatics Analysis Reveals Therapeutic Implications in COPD Patients With COVID-19
title_full Host Factor Interaction Networks Identified by Integrative Bioinformatics Analysis Reveals Therapeutic Implications in COPD Patients With COVID-19
title_fullStr Host Factor Interaction Networks Identified by Integrative Bioinformatics Analysis Reveals Therapeutic Implications in COPD Patients With COVID-19
title_full_unstemmed Host Factor Interaction Networks Identified by Integrative Bioinformatics Analysis Reveals Therapeutic Implications in COPD Patients With COVID-19
title_short Host Factor Interaction Networks Identified by Integrative Bioinformatics Analysis Reveals Therapeutic Implications in COPD Patients With COVID-19
title_sort host factor interaction networks identified by integrative bioinformatics analysis reveals therapeutic implications in copd patients with covid-19
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733735/
https://www.ncbi.nlm.nih.gov/pubmed/35002688
http://dx.doi.org/10.3389/fphar.2021.718874
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