The microglial P2Y(6) receptor mediates neuronal loss and memory deficits in neurodegeneration

Microglia are implicated in neurodegeneration, potentially by phagocytosing neurons, but it is unclear how to block the detrimental effects of microglia while preserving their beneficial roles. The microglial P2Y(6) receptor (P2Y(6)R) – activated by extracellular UDP released by stressed neurons – i...

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Detalles Bibliográficos
Autores principales: Puigdellívol, Mar, Milde, Stefan, Vilalta, Anna, Cockram, Tom O.J., Allendorf, David H., Lee, Jeffrey Y., Dundee, Jacob M., Pampuščenko, Katryna, Borutaite, Vilmante, Nuthall, Hugh N., Brelstaff, Jack H., Spillantini, Maria Grazia, Brown, Guy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733854/
https://www.ncbi.nlm.nih.gov/pubmed/34965424
http://dx.doi.org/10.1016/j.celrep.2021.110148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733854/
https://www.ncbi.nlm.nih.gov/pubmed/34965424
http://dx.doi.org/10.1016/j.celrep.2021.110148

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