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Post-COVID-19 psychiatric and cognitive morbidity: Preliminary findings from a Brazilian cohort study
OBJECTIVE: The present study aims to investigate the occurrence of psychiatric and cognitive impairments in a cohort of survivors of moderate or severe forms of COVID-19. METHOD: 425 adults were assessed 6 to 9 months after hospital discharge with a structured psychiatric interview, psychometric tes...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8734055/ https://www.ncbi.nlm.nih.gov/pubmed/35134702 http://dx.doi.org/10.1016/j.genhosppsych.2022.01.002 |
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author | Damiano, Rodolfo Furlan Caruso, Maria Julia Guimarães Cincoto, Alissom Vitti de Almeida Rocca, Cristiana Castanho de Pádua Serafim, Antonio Bacchi, Pedro Guedes, Bruno F. Brunoni, André R. Pan, Pedro Mario Nitrini, Ricardo Beach, Scott Fricchione, Gregory Busatto, Geraldo Miguel, Euripedes Constantino Forlenza, Orestes V. |
author_facet | Damiano, Rodolfo Furlan Caruso, Maria Julia Guimarães Cincoto, Alissom Vitti de Almeida Rocca, Cristiana Castanho de Pádua Serafim, Antonio Bacchi, Pedro Guedes, Bruno F. Brunoni, André R. Pan, Pedro Mario Nitrini, Ricardo Beach, Scott Fricchione, Gregory Busatto, Geraldo Miguel, Euripedes Constantino Forlenza, Orestes V. |
author_sort | Damiano, Rodolfo Furlan |
collection | PubMed |
description | OBJECTIVE: The present study aims to investigate the occurrence of psychiatric and cognitive impairments in a cohort of survivors of moderate or severe forms of COVID-19. METHOD: 425 adults were assessed 6 to 9 months after hospital discharge with a structured psychiatric interview, psychometric tests and a cognitive battery. A large, multidisciplinary, set of clinical data depicting the acute phase of the disease, along with relevant psychosocial variables, were used to predict psychiatric and cognitive outcomes using the ‘Least Absolute Shrinkage and Selection Operator’ (LASSO) method. RESULTS: Diagnoses of ‘depression’, ‘generalized anxiety disorder’ and ‘post-traumatic stress disorder’ were established respectively in 8%, 15.5% and 13.6% of the sample. After pandemic onset (i.e., within the previous year), the prevalence of ‘depression’ and ‘generalized anxiety disorder’ were 2.56% and 8.14%, respectively. Memory decline was subjectively reported by 51.1% of the patients. Psychiatric or cognitive outcomes were not associated with any clinical variables related to the severity of acute-phase disease, nor by disease-related psychosocial stressors. CONCLUSIONS: This is the first study to access rates of psychiatric and cognitive morbidity in the long-term outcome after moderate or severe forms of COVID-19 using standardized measures. As a key finding, there was no significant association between clinical severity in the acute-phase of SARS-CoV-2 infection and the neuropsychiatric impairment 6 to 9 months thereafter. |
format | Online Article Text |
id | pubmed-8734055 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87340552022-01-06 Post-COVID-19 psychiatric and cognitive morbidity: Preliminary findings from a Brazilian cohort study Damiano, Rodolfo Furlan Caruso, Maria Julia Guimarães Cincoto, Alissom Vitti de Almeida Rocca, Cristiana Castanho de Pádua Serafim, Antonio Bacchi, Pedro Guedes, Bruno F. Brunoni, André R. Pan, Pedro Mario Nitrini, Ricardo Beach, Scott Fricchione, Gregory Busatto, Geraldo Miguel, Euripedes Constantino Forlenza, Orestes V. Gen Hosp Psychiatry Article OBJECTIVE: The present study aims to investigate the occurrence of psychiatric and cognitive impairments in a cohort of survivors of moderate or severe forms of COVID-19. METHOD: 425 adults were assessed 6 to 9 months after hospital discharge with a structured psychiatric interview, psychometric tests and a cognitive battery. A large, multidisciplinary, set of clinical data depicting the acute phase of the disease, along with relevant psychosocial variables, were used to predict psychiatric and cognitive outcomes using the ‘Least Absolute Shrinkage and Selection Operator’ (LASSO) method. RESULTS: Diagnoses of ‘depression’, ‘generalized anxiety disorder’ and ‘post-traumatic stress disorder’ were established respectively in 8%, 15.5% and 13.6% of the sample. After pandemic onset (i.e., within the previous year), the prevalence of ‘depression’ and ‘generalized anxiety disorder’ were 2.56% and 8.14%, respectively. Memory decline was subjectively reported by 51.1% of the patients. Psychiatric or cognitive outcomes were not associated with any clinical variables related to the severity of acute-phase disease, nor by disease-related psychosocial stressors. CONCLUSIONS: This is the first study to access rates of psychiatric and cognitive morbidity in the long-term outcome after moderate or severe forms of COVID-19 using standardized measures. As a key finding, there was no significant association between clinical severity in the acute-phase of SARS-CoV-2 infection and the neuropsychiatric impairment 6 to 9 months thereafter. Elsevier Inc. 2022 2022-01-06 /pmc/articles/PMC8734055/ /pubmed/35134702 http://dx.doi.org/10.1016/j.genhosppsych.2022.01.002 Text en © 2022 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Damiano, Rodolfo Furlan Caruso, Maria Julia Guimarães Cincoto, Alissom Vitti de Almeida Rocca, Cristiana Castanho de Pádua Serafim, Antonio Bacchi, Pedro Guedes, Bruno F. Brunoni, André R. Pan, Pedro Mario Nitrini, Ricardo Beach, Scott Fricchione, Gregory Busatto, Geraldo Miguel, Euripedes Constantino Forlenza, Orestes V. Post-COVID-19 psychiatric and cognitive morbidity: Preliminary findings from a Brazilian cohort study |
title | Post-COVID-19 psychiatric and cognitive morbidity: Preliminary findings from a Brazilian cohort study |
title_full | Post-COVID-19 psychiatric and cognitive morbidity: Preliminary findings from a Brazilian cohort study |
title_fullStr | Post-COVID-19 psychiatric and cognitive morbidity: Preliminary findings from a Brazilian cohort study |
title_full_unstemmed | Post-COVID-19 psychiatric and cognitive morbidity: Preliminary findings from a Brazilian cohort study |
title_short | Post-COVID-19 psychiatric and cognitive morbidity: Preliminary findings from a Brazilian cohort study |
title_sort | post-covid-19 psychiatric and cognitive morbidity: preliminary findings from a brazilian cohort study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8734055/ https://www.ncbi.nlm.nih.gov/pubmed/35134702 http://dx.doi.org/10.1016/j.genhosppsych.2022.01.002 |
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