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Restricting tumor lactic acid metabolism using dichloroacetate improves T cell functions

BACKGROUND: Lactic acid produced by tumors has been shown to overcome immune surveillance, by suppressing the activation and function of T cells in the tumor microenvironment. The strategies employed to impair tumor cell glycolysis could improve immunosurveillance and tumor growth regulation. Dichlo...

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Detalles Bibliográficos
Autores principales:	Rostamian, Hosein, Khakpoor-Koosheh, Mohammad, Jafarzadeh, Leila, Masoumi, Elham, Fallah-Mehrjardi, Keyvan, Tavassolifar, Mohammad Javad, M. Pawelek, John, Mirzaei, Hamid Reza, Hadjati, Jamshid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8734242/ https://www.ncbi.nlm.nih.gov/pubmed/34991504 http://dx.doi.org/10.1186/s12885-021-09151-2

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