The clinical significance of adenomatous polyposis coli (APC) and catenin Beta 1 (CTNNB1) genetic aberrations in patients with melanoma

BACKGROUND: Melanoma-intrinsic activated β-catenin pathway, the product of the catenin beta 1 (CTNNB1) gene, has been associated with low/absent tumor-infiltrating lymphocytes, accelerated tumor growth, metastases development, and resistance to anti-PD-L1/anti-CTLA-4 agents in mouse melanoma models....

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Detalles Bibliográficos
Autores principales: Karachaliou, Georgia Sofia, Alkallas, Rached, Carroll, Sarah B., Caressi, Chongshan, Zakria, Danny, Patel, Nirali M., Trembath, Dimitri G., Ezzell, Jennifer A., Pegna, Guillaume J., Googe, Paul B., Galeotti, Jonathan P., Ayvali, Fatih, Collichio, Frances A., Lee, Carrie B., Ollila, David W., Gulley, Margaret L., Johnson, Douglas B., Kim, Kevin B., Watson, Ian R., Moschos, Stergios J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8734243/
https://www.ncbi.nlm.nih.gov/pubmed/34986841
http://dx.doi.org/10.1186/s12885-021-08908-z

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