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Nafamostat reduces systemic inflammation in TLR7-mediated virus-like illness
BACKGROUND: The serine protease inhibitor nafamostat has been proposed as a treatment for COVID-19, by inhibiting TMPRSS2-mediated viral cell entry. Nafamostat has been shown to have other, immunomodulatory effects, which may be beneficial for treatment, however animal models of ssRNA virus infectio...
Autores principales: | Yates, Abi G., Weglinski, Caroline M., Ying, Yuxin, Dunstan, Isobel K., Strekalova, Tatyana, Anthony, Daniel C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8734544/ https://www.ncbi.nlm.nih.gov/pubmed/34991643 http://dx.doi.org/10.1186/s12974-021-02357-y |
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