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COCARDE Study–Cardiac Imaging Phenotype in Patients With COVID-19: Protocol for a Prospective Observational Study
BACKGROUND: The effects of SARS-CoV-2 (COVID-19) on the myocardium and their role in the clinical course of infected patients are still unknown. The severity of SARS-CoV-2 is driven by hyperinflammation, and the effects of SARS-CoV-2 on the myocardium may be significant. This study proposes to use b...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
JMIR Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8734604/ https://www.ncbi.nlm.nih.gov/pubmed/34751159 http://dx.doi.org/10.2196/24931 |
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author | Lairez, Olivier Blanchard, Virginie Balardy, Laurent Vardon-Bounes, Fanny Cazalbou, Stéphanie Ruiz, Stéphanie Collot, Samia Houard, Valérie Rolland, Yves Conil, Jean-Marie Minville, Vincent |
author_facet | Lairez, Olivier Blanchard, Virginie Balardy, Laurent Vardon-Bounes, Fanny Cazalbou, Stéphanie Ruiz, Stéphanie Collot, Samia Houard, Valérie Rolland, Yves Conil, Jean-Marie Minville, Vincent |
author_sort | Lairez, Olivier |
collection | PubMed |
description | BACKGROUND: The effects of SARS-CoV-2 (COVID-19) on the myocardium and their role in the clinical course of infected patients are still unknown. The severity of SARS-CoV-2 is driven by hyperinflammation, and the effects of SARS-CoV-2 on the myocardium may be significant. This study proposes to use bedside observations and biomarkers to characterize the association of COVID-19 with myocardial injury. OBJECTIVE: The aim of the study is to describe the myocardial function and its evolution over time in patients infected with SARS-CoV-2 and to investigate the link between inflammation and cardiac injury. METHODS: This prospective, monocentric, observational study enrolled 150 patients with suspected or confirmed SARS-CoV-2 infection at Toulouse University Hospital, Toulouse, France. Patients admitted to the intensive care unit (ICU), regular cardiologic ward, and geriatric ward of our tertiary university hospital were included during the pandemic period. Blood sampling, electrocardiography, echocardiography, and morphometric and demographic data were prospectively collected. RESULTS: A total of 100 patients were included. The final enrolment day was March 31, 2020, with first report of results at the end of the first quarter of 2021. The first echocardiographic results at admission of 31 patients of the COCARDE-ICU substudy population show that biological myocardial injury in COVID-19 has low functional impact on left ventricular systolic function. CONCLUSIONS: A better understanding of the effects of COVID-19 on myocardial function and its link with inflammation would improve patient follow-up and care. TRIAL REGISTRATION: Clinicaltrials.gov NCT04358952; https://clinicaltrials.gov/ct2/show/NCT04358952 INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/24931 |
format | Online Article Text |
id | pubmed-8734604 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | JMIR Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-87346042022-01-21 COCARDE Study–Cardiac Imaging Phenotype in Patients With COVID-19: Protocol for a Prospective Observational Study Lairez, Olivier Blanchard, Virginie Balardy, Laurent Vardon-Bounes, Fanny Cazalbou, Stéphanie Ruiz, Stéphanie Collot, Samia Houard, Valérie Rolland, Yves Conil, Jean-Marie Minville, Vincent JMIR Res Protoc Protocol BACKGROUND: The effects of SARS-CoV-2 (COVID-19) on the myocardium and their role in the clinical course of infected patients are still unknown. The severity of SARS-CoV-2 is driven by hyperinflammation, and the effects of SARS-CoV-2 on the myocardium may be significant. This study proposes to use bedside observations and biomarkers to characterize the association of COVID-19 with myocardial injury. OBJECTIVE: The aim of the study is to describe the myocardial function and its evolution over time in patients infected with SARS-CoV-2 and to investigate the link between inflammation and cardiac injury. METHODS: This prospective, monocentric, observational study enrolled 150 patients with suspected or confirmed SARS-CoV-2 infection at Toulouse University Hospital, Toulouse, France. Patients admitted to the intensive care unit (ICU), regular cardiologic ward, and geriatric ward of our tertiary university hospital were included during the pandemic period. Blood sampling, electrocardiography, echocardiography, and morphometric and demographic data were prospectively collected. RESULTS: A total of 100 patients were included. The final enrolment day was March 31, 2020, with first report of results at the end of the first quarter of 2021. The first echocardiographic results at admission of 31 patients of the COCARDE-ICU substudy population show that biological myocardial injury in COVID-19 has low functional impact on left ventricular systolic function. CONCLUSIONS: A better understanding of the effects of COVID-19 on myocardial function and its link with inflammation would improve patient follow-up and care. TRIAL REGISTRATION: Clinicaltrials.gov NCT04358952; https://clinicaltrials.gov/ct2/show/NCT04358952 INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/24931 JMIR Publications 2022-01-06 /pmc/articles/PMC8734604/ /pubmed/34751159 http://dx.doi.org/10.2196/24931 Text en ©Olivier Lairez, Virginie Blanchard, Laurent Balardy, Fanny Vardon-Bounes, Stéphanie Cazalbou, Stéphanie Ruiz, Samia Collot, Valérie Houard, Yves Rolland, Jean-Marie Conil, Vincent Minville. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 06.01.2022. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Research Protocols, is properly cited. The complete bibliographic information, a link to the original publication on https://www.researchprotocols.org, as well as this copyright and license information must be included. |
spellingShingle | Protocol Lairez, Olivier Blanchard, Virginie Balardy, Laurent Vardon-Bounes, Fanny Cazalbou, Stéphanie Ruiz, Stéphanie Collot, Samia Houard, Valérie Rolland, Yves Conil, Jean-Marie Minville, Vincent COCARDE Study–Cardiac Imaging Phenotype in Patients With COVID-19: Protocol for a Prospective Observational Study |
title | COCARDE Study–Cardiac Imaging Phenotype in Patients With COVID-19: Protocol for a Prospective Observational Study |
title_full | COCARDE Study–Cardiac Imaging Phenotype in Patients With COVID-19: Protocol for a Prospective Observational Study |
title_fullStr | COCARDE Study–Cardiac Imaging Phenotype in Patients With COVID-19: Protocol for a Prospective Observational Study |
title_full_unstemmed | COCARDE Study–Cardiac Imaging Phenotype in Patients With COVID-19: Protocol for a Prospective Observational Study |
title_short | COCARDE Study–Cardiac Imaging Phenotype in Patients With COVID-19: Protocol for a Prospective Observational Study |
title_sort | cocarde study–cardiac imaging phenotype in patients with covid-19: protocol for a prospective observational study |
topic | Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8734604/ https://www.ncbi.nlm.nih.gov/pubmed/34751159 http://dx.doi.org/10.2196/24931 |
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