Long-term adaptation following influenza A virus host shifts results in increased within-host viral fitness due to higher replication rates, broader dissemination within the respiratory epithelium and reduced tissue damage

The mechanisms and consequences of genome evolution on viral fitness following host shifts are poorly understood. In addition, viral fitness -the ability of an organism to reproduce and survive- is multifactorial and thus difficult to quantify. Influenza A viruses (IAVs) circulate broadly among wild...

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Detalles Bibliográficos
Autores principales: Amat, Julien A. R., Patton, Veronica, Chauché, Caroline, Goldfarb, Daniel, Crispell, Joanna, Gu, Quan, Coburn, Alice M., Gonzalez, Gaelle, Mair, Daniel, Tong, Lily, Martinez-Sobrido, Luis, Marshall, John F., Marchesi, Francesco, Murcia, Pablo R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8735595/
https://www.ncbi.nlm.nih.gov/pubmed/34919598
http://dx.doi.org/10.1371/journal.ppat.1010174

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