Serum miR-34a-5p and miR-199a-3p as new biomarkers of neonatal sepsis

BACKGROUND: Neonatal sepsis is a serious condition. Recent clinical studies have indicated that microRNAs (miRNAs) are key players in the pathogenesis of sepsis, which could be used as biomarkers for this condition. PATIENTS AND METHODS: A total of 90 neonates with sepsis and 90 healthy neonates wer...

Descripción completa

Detalles Bibliográficos
Autores principales: Abdelaleem, Omayma O., Mohammed, Shereen Rashad, El Sayed, Hassan S., Hussein, Sherin Khamis, Ali, Doaa Y., Abdelwahed, Mostafa Y., Gaber, Sylvana N., Hemeda, Nada F., El-Hmid, Rehab G. Abd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8735601/
https://www.ncbi.nlm.nih.gov/pubmed/34990478
http://dx.doi.org/10.1371/journal.pone.0262339
Descripción
Sumario:BACKGROUND: Neonatal sepsis is a serious condition. Recent clinical studies have indicated that microRNAs (miRNAs) are key players in the pathogenesis of sepsis, which could be used as biomarkers for this condition. PATIENTS AND METHODS: A total of 90 neonates with sepsis and 90 healthy neonates were enrolled in this study. qRT-PCR was performed to measure the expression levels of serum miR-34a-5p and miR-199a-3p. RESULTS: miR-34a-5p and miR-199a-3p serum levels were significantly reduced in neonates with sepsis compared with those in healthy neonates (P = 0.006 and P = 0.001, respectively). Significant correlations of miR-34a-5p and miR-199a-3p with each of TLC, RDW, RBS, and C-reactive protein (CRP) as well as SNAPII were observed, indicating their associations with the severity of neonatal sepsis. CONCLUSION: miR-34a-5p and miR-199a-3p may be useful as novel biomarkers in neonatal sepsis and may provide a new direction for its treatment.

Ejemplares similares