Cargando…

Analysis of coding variants in the human FTO gene from the gnomAD database

Single nucleotide polymorphisms (SNPs) in the first intron of the FTO gene reported in 2007 continue to be the known variants with the greatest effect on adiposity in different human populations. Coding variants in the FTO gene, on the other hand, have been little explored, although data from comple...

Descripción completa

Detalles Bibliográficos
Autores principales:	Souza Junior, Mauro Lúcio Ferreira, de Sousa, Jaime Viana, Guerreiro, João Farias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8735611/ https://www.ncbi.nlm.nih.gov/pubmed/34990463 http://dx.doi.org/10.1371/journal.pone.0248610

Ejemplares similares

Variant interpretation using population databases: Lessons from gnomAD
por: Gudmundsson, Sanna, et al.
Publicado: (2021)

Prevalence estimates of putatively pathogenic leptin variants in the gnomAD database
por: Rajcsanyi, Luisa Sophie, et al.
Publicado: (2022)

Differential Domain Distribution of gnomAD- and Disease-Linked Connexin Missense Variants
por: Bai, Donglin, et al.
Publicado: (2021)

Mitochondrial DNA variation across 56,434 individuals in gnomAD
por: Laricchia, Kristen M., et al.
Publicado: (2022)

Estimated birth prevalence of Menkes disease and ATP7A-related disorders based on the Genome Aggregation Database (gnomAD)
por: Kaler, Stephen G., et al.
Publicado: (2020)

Major sex differences in allele frequencies for X chromosomal variants in both the 1000 Genomes Project and gnomAD
por: Wang, Zhong, et al.
Publicado: (2022)

Annotation of 1350 Common Genetic Variants of the 19 ALDH Multigene Family from Global Human Genome Aggregation Database (gnomAD)
por: Chen, Che-Hong, et al.
Publicado: (2021)

Low frequency of treatable pediatric disease alleles in gnomAD: An opportunity for future genomic screening of newborns
por: Gold, Nina B., et al.
Publicado: (2021)

Carrier frequency and incidence estimation of familial hemophagocytic lymphohistiocytosis in East Asian populations by genome aggregation database (gnomAD) based analysis
por: Park, Jong Eun, et al.
Publicado: (2022)

Carrier frequency and incidence estimation of Smith–Lemli–Opitz syndrome in East Asian populations by Genome Aggregation Database (gnomAD) based analysis
por: Park, Jong Eun, et al.
Publicado: (2021)

GNOM/FEWER ROOTS is Required for the Establishment of an Auxin Response Maximum for Arabidopsis Lateral Root Initiation
por: Okumura, Ken-ichi, et al.
Publicado: (2013)

Connected function of PRAF/RLD and GNOM in membrane trafficking controls intrinsic cell polarity in plants
por: Wang, Lu, et al.
Publicado: (2022)

Screening for Coding Variants in FTO and SH2B1 Genes in Chinese Patients with Obesity
por: Zheng, Zhaojing, et al.
Publicado: (2013)

Association of FTO and PPARG polymorphisms with obesity in Portuguese women
por: Carlos, Fábio Ferreira, et al.
Publicado: (2013)

Association between a frequent variant of the FTO gene and anthropometric phenotypes in Brazilian children
por: da Silva, Carmela Farias, et al.
Publicado: (2013)

Detecting tandem repeat variants in coding regions using code-adVNTR
por: Park, Jonghun, et al.
Publicado: (2022)

FTO Obesity Risk Variants Are Linked to Adipocyte IRX3 Expression and BMI of Children - Relevance of FTO Variants to Defend Body Weight in Lean Children?
por: Landgraf, Kathrin, et al.
Publicado: (2016)

Inducible knock-down of GNOM during root formation reveals tissue-specific response to auxin transport and its modulation of local auxin biosynthesis
por: Guo, Jingzhe, et al.
Publicado: (2014)

FTO Variants Are Associated With Obesity in the Chinese and Malay Populations in Singapore
por: Tan, Jonathan T., et al.
Publicado: (2008)

Association of FTO gene variants with body composition in UK twins
por: Livshits, Gregory, et al.
Publicado: (2012)

Commentary: FTO obesity variant circuitry and adipocyte browning in humans
por: Laber, Samantha, et al.
Publicado: (2015)

Case report: A novel biallelic FTO variant causing multisystem anomalies with severe epilepsy, widening the spectrum of FTO syndrome
por: Mayman, Naomi, et al.
Publicado: (2023)

Investigation of mutations in the HBB gene using the 1,000 genomes database
por: Carlice-dos-Reis, Tânia, et al.
Publicado: (2017)

Common Variant of FTO Gene, rs9939609, and Obesity in Pakistani Females
por: Shahid, Adeela, et al.
Publicado: (2013)

Association of HTTLPR, BDNF, and FTO Genetic Variants with Completed Suicide in Slovakia
por: Bednarova, Aneta, et al.
Publicado: (2023)

Pharmacological Inhibition of FTO
por: McMurray, Fiona, et al.
Publicado: (2015)

An Obesity-Related FTO Variant and the Risk of Preeclampsia in a Finnish Study Population
por: Klemetti, Miira, et al.
Publicado: (2011)

FTO Gene Variants Are Associated with PCOS Susceptibility and Hyperandrogenemia in Young Korean Women
por: Song, Do Kyeong, et al.
Publicado: (2014)

Genetic Variants in the Fat and Obesity Associated (FTO) Gene and Risk of Alzheimer's Disease
por: Reitz, Christiane, et al.
Publicado: (2012)

An FTO Gene Variant Moderates the Association between Parental Restriction and Child BMI
por: Tovar, Alison, et al.
Publicado: (2016)

Common FTO rs9939609 variant and risk of type 2 diabetes in Palestine
por: Sabarneh, Anas, et al.
Publicado: (2018)

Effect of FTO rs9939609 variant on insulin resistance in obese female adolescents
por: Iskandar, Kristy, et al.
Publicado: (2018)

Association of FTO common variant (rs9939609) with body fat in Turkish individuals
por: AĞAGÜNDÜZ, Duygu, et al.
Publicado: (2019)

Investigation of the role of polymorphic variants FTO gene in schizophrenia patients with metabolic syndrome
por: Pozhidaev, I., et al.
Publicado: (2021)

Increased meso-striatal connectivity mediates trait impulsivity in FTO variant carriers
por: Edwin Thanarajah, Sharmili, et al.
Publicado: (2023)

Novel SNP in the coding region of the FTO gene is associated with marbling score in Hanwoo (Korean cattle)
por: Chung, Eui-Ryong
Publicado: (2014)

Association between the FTO gene polymorphism and obesity in Brazilian adolescents from the Northeast region()()
por: Rodrigues, Liliane dos Santos, et al.
Publicado: (2019)

FTO and MC4R Gene Variants Are Associated with Obesity in Polycystic Ovary Syndrome
por: Ewens, Kathryn G., et al.
Publicado: (2011)

Dietary Energy Density Affects Fat Mass in Early Adolescence and Is Not Modified by FTO Variants
por: Johnson, Laura, et al.
Publicado: (2009)

Erratum to “An Obesity-Related FTO Variant and the Risk of Preeclampsia in a Finnish Study Population”
por: Klemetti, Miira, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_n09q6acg6k6u5amojht4c1n3bu