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Keratin–Chitosan Microcapsules via Membrane Emulsification and Interfacial Complexation

[Image: see text] The continuous fabrication via membrane emulsification of stable microcapsules using renewable, biodegradable biopolymer wall materials keratin and chitosan is reported here for the first time. Microcapsule formation was based on opposite charge interactions between keratin and chi...

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Autores principales: Wilson, Amy, Ekanem, Ekanem E., Mattia, Davide, Edler, Karen J., Scott, Janet L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8735752/
https://www.ncbi.nlm.nih.gov/pubmed/35024251
http://dx.doi.org/10.1021/acssuschemeng.1c05304
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author Wilson, Amy
Ekanem, Ekanem E.
Mattia, Davide
Edler, Karen J.
Scott, Janet L.
author_facet Wilson, Amy
Ekanem, Ekanem E.
Mattia, Davide
Edler, Karen J.
Scott, Janet L.
author_sort Wilson, Amy
collection PubMed
description [Image: see text] The continuous fabrication via membrane emulsification of stable microcapsules using renewable, biodegradable biopolymer wall materials keratin and chitosan is reported here for the first time. Microcapsule formation was based on opposite charge interactions between keratin and chitosan, which formed polyelectrolyte complexes when solutions were mixed at pH 5.5. Interfacial complexation was induced by transfer of keratin-stabilized primary emulsion droplets to chitosan solution, where the deposition of chitosan around droplets formed a core–shell structure. Capsule formation was demonstrated both in batch and continuous systems, with the latter showing a productivity up to 4.5 million capsules per minute. Keratin–chitosan microcapsules (in the 30–120 μm range) released less encapsulated nile red than the keratin-only emulsion, whereas microcapsules cross-linked with glutaraldehyde were stable for at least 6 months, and a greater amount of cross-linker was associated with enhanced dye release under the application of force due to increased shell brittleness. In light of recent bans involving microplastics in cosmetics, applications may be found in skin-pH formulas for the protection of oils or oil-soluble compounds, with a possible mechanical rupture release mechanism (e.g., rubbing on skin).
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spelling pubmed-87357522022-01-10 Keratin–Chitosan Microcapsules via Membrane Emulsification and Interfacial Complexation Wilson, Amy Ekanem, Ekanem E. Mattia, Davide Edler, Karen J. Scott, Janet L. ACS Sustain Chem Eng [Image: see text] The continuous fabrication via membrane emulsification of stable microcapsules using renewable, biodegradable biopolymer wall materials keratin and chitosan is reported here for the first time. Microcapsule formation was based on opposite charge interactions between keratin and chitosan, which formed polyelectrolyte complexes when solutions were mixed at pH 5.5. Interfacial complexation was induced by transfer of keratin-stabilized primary emulsion droplets to chitosan solution, where the deposition of chitosan around droplets formed a core–shell structure. Capsule formation was demonstrated both in batch and continuous systems, with the latter showing a productivity up to 4.5 million capsules per minute. Keratin–chitosan microcapsules (in the 30–120 μm range) released less encapsulated nile red than the keratin-only emulsion, whereas microcapsules cross-linked with glutaraldehyde were stable for at least 6 months, and a greater amount of cross-linker was associated with enhanced dye release under the application of force due to increased shell brittleness. In light of recent bans involving microplastics in cosmetics, applications may be found in skin-pH formulas for the protection of oils or oil-soluble compounds, with a possible mechanical rupture release mechanism (e.g., rubbing on skin). American Chemical Society 2021-12-01 2021-12-13 /pmc/articles/PMC8735752/ /pubmed/35024251 http://dx.doi.org/10.1021/acssuschemeng.1c05304 Text en © 2021 American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Wilson, Amy
Ekanem, Ekanem E.
Mattia, Davide
Edler, Karen J.
Scott, Janet L.
Keratin–Chitosan Microcapsules via Membrane Emulsification and Interfacial Complexation
title Keratin–Chitosan Microcapsules via Membrane Emulsification and Interfacial Complexation
title_full Keratin–Chitosan Microcapsules via Membrane Emulsification and Interfacial Complexation
title_fullStr Keratin–Chitosan Microcapsules via Membrane Emulsification and Interfacial Complexation
title_full_unstemmed Keratin–Chitosan Microcapsules via Membrane Emulsification and Interfacial Complexation
title_short Keratin–Chitosan Microcapsules via Membrane Emulsification and Interfacial Complexation
title_sort keratin–chitosan microcapsules via membrane emulsification and interfacial complexation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8735752/
https://www.ncbi.nlm.nih.gov/pubmed/35024251
http://dx.doi.org/10.1021/acssuschemeng.1c05304
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