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Effect of calcium and magnesium on inflammatory cytokines in accidentally multiple fracture adults: A short-term follow-up

Calcium (Ca) and magnesium (Mg), which play an important role in several cellular processes, is essential for normal development of the skeleton and maintenance of tissue homeostasis. Deficiency of these elements might delay bone fracture recovery or accelerates bone loss. We aimed to examine whethe...

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Autores principales: Song, Yongxing, Xu, Long, Jin, Xin, Chen, Deqing, Jin, Xiuhui, Xu, Guangtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8735799/
https://www.ncbi.nlm.nih.gov/pubmed/35029924
http://dx.doi.org/10.1097/MD.0000000000028538
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author Song, Yongxing
Xu, Long
Jin, Xin
Chen, Deqing
Jin, Xiuhui
Xu, Guangtao
author_facet Song, Yongxing
Xu, Long
Jin, Xin
Chen, Deqing
Jin, Xiuhui
Xu, Guangtao
author_sort Song, Yongxing
collection PubMed
description Calcium (Ca) and magnesium (Mg), which play an important role in several cellular processes, is essential for normal development of the skeleton and maintenance of tissue homeostasis. Deficiency of these elements might delay bone fracture recovery or accelerates bone loss. We aimed to examine whether supplementation of trace element (TE) promotes fracture healing in accidentally fracturing adults by involvement of inflammatory mechanism. A short-term follow-up in clinic was performed. Totally, 117 subjects diagnosed with multiple fractures by traffic accidents were recruited in this study. Serum Ca and Mg levels were measured by inductively coupled plasma atomic emission spectrophotometry. Short-term changes such as serum C-reactive protein, interleukin (IL)-1β, IL-6, and tumor necrosis factor alpha in normal treatment and TE supplement groups were detected by enzyme-linked immunosorbent assay. Student t test and the Spearman correlation were performed to analyze the data. Significantly negative correlations between Ca (r = 0.7032; P < .001) and Mg (r = 0.2719; P < .05) and injury severity score were observed. Serum Ca and Mg were significantly increased at Day 5, 7, and 9 following TE supplements. After treatment, serum C-reactive protein, IL-1β, IL-6, and tumor necrosis factor alpha were significantly reduced whereas cytokine levels of the TE supplement group were found to be lower than that of the normal treatment group after Day 3. These findings suggest that Ca and Mg levels are associated with the injury severity of multiple fractures, and the supplement could reduce the inflammation, which may be beneficial for the bone recovery and disease process.
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spelling pubmed-87357992022-01-11 Effect of calcium and magnesium on inflammatory cytokines in accidentally multiple fracture adults: A short-term follow-up Song, Yongxing Xu, Long Jin, Xin Chen, Deqing Jin, Xiuhui Xu, Guangtao Medicine (Baltimore) 7100 Calcium (Ca) and magnesium (Mg), which play an important role in several cellular processes, is essential for normal development of the skeleton and maintenance of tissue homeostasis. Deficiency of these elements might delay bone fracture recovery or accelerates bone loss. We aimed to examine whether supplementation of trace element (TE) promotes fracture healing in accidentally fracturing adults by involvement of inflammatory mechanism. A short-term follow-up in clinic was performed. Totally, 117 subjects diagnosed with multiple fractures by traffic accidents were recruited in this study. Serum Ca and Mg levels were measured by inductively coupled plasma atomic emission spectrophotometry. Short-term changes such as serum C-reactive protein, interleukin (IL)-1β, IL-6, and tumor necrosis factor alpha in normal treatment and TE supplement groups were detected by enzyme-linked immunosorbent assay. Student t test and the Spearman correlation were performed to analyze the data. Significantly negative correlations between Ca (r = 0.7032; P < .001) and Mg (r = 0.2719; P < .05) and injury severity score were observed. Serum Ca and Mg were significantly increased at Day 5, 7, and 9 following TE supplements. After treatment, serum C-reactive protein, IL-1β, IL-6, and tumor necrosis factor alpha were significantly reduced whereas cytokine levels of the TE supplement group were found to be lower than that of the normal treatment group after Day 3. These findings suggest that Ca and Mg levels are associated with the injury severity of multiple fractures, and the supplement could reduce the inflammation, which may be beneficial for the bone recovery and disease process. Lippincott Williams & Wilkins 2022-01-07 /pmc/articles/PMC8735799/ /pubmed/35029924 http://dx.doi.org/10.1097/MD.0000000000028538 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle 7100
Song, Yongxing
Xu, Long
Jin, Xin
Chen, Deqing
Jin, Xiuhui
Xu, Guangtao
Effect of calcium and magnesium on inflammatory cytokines in accidentally multiple fracture adults: A short-term follow-up
title Effect of calcium and magnesium on inflammatory cytokines in accidentally multiple fracture adults: A short-term follow-up
title_full Effect of calcium and magnesium on inflammatory cytokines in accidentally multiple fracture adults: A short-term follow-up
title_fullStr Effect of calcium and magnesium on inflammatory cytokines in accidentally multiple fracture adults: A short-term follow-up
title_full_unstemmed Effect of calcium and magnesium on inflammatory cytokines in accidentally multiple fracture adults: A short-term follow-up
title_short Effect of calcium and magnesium on inflammatory cytokines in accidentally multiple fracture adults: A short-term follow-up
title_sort effect of calcium and magnesium on inflammatory cytokines in accidentally multiple fracture adults: a short-term follow-up
topic 7100
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8735799/
https://www.ncbi.nlm.nih.gov/pubmed/35029924
http://dx.doi.org/10.1097/MD.0000000000028538
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