Immunity to SARS-CoV-2 up to 15 months after infection

Information concerning the longevity of immunity to SARS-CoV-2 following natural infection may have considerable implications for durability of immunity induced by vaccines. Here, we monitored the SARS-CoV-2 specific immune response in COVID-19 patients followed up to 15 months after symptoms onset....

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Detalles Bibliográficos
Autores principales: Marcotte, Harold, Piralla, Antonio, Zuo, Fanglei, Du, Likun, Cassaniti, Irene, Wan, Hui, Kumagai-Braesh, Makiko, Andréll, Juni, Percivalle, Elena, Sammartino, Josè Camilla, Wang, Yating, Vlachiotis, Stelios, Attevall, Janine, Bergami, Federica, Ferrari, Alessandro, Colaneri, Marta, Vecchia, Marco, Sambo, Margherita, Zuccaro, Valentina, Asperges, Erika, Bruno, Raffaele, Oggionni, Tiberio, Meloni, Federica, Abolhassani, Hassan, Bertoglio, Federico, Schubert, Maren, Calzolai, Luigi, Varani, Luca, Hust, Michael, Xue, Yintong, Hammarström, Lennart, Baldanti, Fausto, Pan-Hammarström, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8736281/
https://www.ncbi.nlm.nih.gov/pubmed/35018336
http://dx.doi.org/10.1016/j.isci.2022.103743
Descripción
Sumario:Information concerning the longevity of immunity to SARS-CoV-2 following natural infection may have considerable implications for durability of immunity induced by vaccines. Here, we monitored the SARS-CoV-2 specific immune response in COVID-19 patients followed up to 15 months after symptoms onset. Following a peak at day 15–28 postinfection, the IgG antibody response and plasma neutralizing titers gradually decreased over time but stabilized after 6 months. Compared to G614, plasma neutralizing titers were more than 8-fold lower against variants Beta, Gamma, and Delta. SARS-CoV-2-specific memory B and T cells persisted in the majority of patients up to 15 months although a significant decrease in specific T cells, but not B cells, was observed between 6 and 15 months. Antiviral specific immunity, especially memory B cells in COVID-19 convalescent patients, is long-lasting, but some variants of concern may at least partially escape the neutralizing activity of plasma antibodies.

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