Mutational landscape and in silico structure models of SARS-CoV-2 spike receptor binding domain reveal key molecular determinants for virus-host interaction

BACKGROUND: SARS-CoV-2, the causative agent of COVID-19 pandemic is a RNA virus prone to mutations. Formation of a stable binding interface between the Receptor Binding Domain (RBD) of SARS-CoV-2 Spike (S) protein and Angiotensin-Converting Enzyme 2 (ACE2) of host is pivotal for viral entry. RBD has...

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Detalles Bibliográficos
Autores principales: Nelson-Sathi, Shijulal, Umasankar, P. K., Sreekumar, E., Nair, R. Radhakrishnan, Joseph, Iype, Nori, Sai Ravi Chandra, Philip, Jamiema Sara, Prasad, Roshny, Navyasree, K. V., Ramesh, Shikha, Pillai, Heera, Ghosh, Sanu, Santosh Kumar, T. R., Pillai, M. Radhakrishna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8736301/
https://www.ncbi.nlm.nih.gov/pubmed/34991443
http://dx.doi.org/10.1186/s12860-021-00403-4

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