Impaired Retrograde Transport Due to Lack of TBC1D5 Contributes to the Trafficking Defect of Lysosomal Cathepsins in Ischemic/Hypoxic Cardiomyocytes

Lysosomal dysfunction has been found in many pathological conditions, and methods to improve lysosomal function have been reported to be protective against infarcted hearts. However, the mechanisms underlying lysosomal dysfunction caused by ischemic injury are far less well-established. The retromer...

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Detalles Bibliográficos
Autores principales: Cui, Lin, Zhang, Qiong, Huang, Yao, Yang, Lei, Zhang, Junhui, Jiang, Xupin, Jia, Jiezhi, Lv, Yanling, Zhang, Dongxia, Huang, Yuesheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8736705/
https://www.ncbi.nlm.nih.gov/pubmed/35004909
http://dx.doi.org/10.3389/fcvm.2021.796254

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