Microglia contribute to the propagation of Aβ into unaffected brain tissue

Microglia appear activated in the vicinity of amyloid beta (Aβ) plaques, but whether microglia contribute to Aβ propagation into unaffected brain regions remains unknown. Using transplantation of wild-type (WT) neurons, we show that Aβ enters WT grafts, and that this is accompanied by microglia infi...

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Detalles Bibliográficos
Autores principales: d’Errico, Paolo, Ziegler-Waldkirch, Stephanie, Aires, Vanessa, Hoffmann, Philippe, Mezö, Charlotte, Erny, Daniel, Monasor, Laura Sebastian, Liebscher, Sabine, Ravi, Vidhya M., Joseph, Kevin, Schnell, Oliver, Kierdorf, Katrin, Staszewski, Ori, Tahirovic, Sabina, Prinz, Marco, Meyer-Luehmann, Melanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8737330/
https://www.ncbi.nlm.nih.gov/pubmed/34811521
http://dx.doi.org/10.1038/s41593-021-00951-0

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