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Clinical implications of alpha, beta, and gamma HPV infection in juvenile onset recurrent respiratory papillomatosis

PURPOSE: The aim of our study was to evaluate the prevalence of different HPV genera—alpha, beta and gamma—in Juvenile onset Recurrent Respiratory Papillomatosis (JoRRP) and examine the association of type and genus-specific viral features with the clinical outcome of disease. METHODS: This retrospe...

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Autores principales: Bertinazzi, Martina, Gheit, Tarik, Polesel, Jerry, McKay-Chopin, Sandrine, Cutrone, Cesare, Sari, Marianna, Sbaraglia, Marta, Tos, Angelo Paolo Dei, Nicolai, Piero, Tommasino, Massimo, Boscolo-Rizzo, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8738360/
https://www.ncbi.nlm.nih.gov/pubmed/34453571
http://dx.doi.org/10.1007/s00405-021-07040-9
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author Bertinazzi, Martina
Gheit, Tarik
Polesel, Jerry
McKay-Chopin, Sandrine
Cutrone, Cesare
Sari, Marianna
Sbaraglia, Marta
Tos, Angelo Paolo Dei
Nicolai, Piero
Tommasino, Massimo
Boscolo-Rizzo, Paolo
author_facet Bertinazzi, Martina
Gheit, Tarik
Polesel, Jerry
McKay-Chopin, Sandrine
Cutrone, Cesare
Sari, Marianna
Sbaraglia, Marta
Tos, Angelo Paolo Dei
Nicolai, Piero
Tommasino, Massimo
Boscolo-Rizzo, Paolo
author_sort Bertinazzi, Martina
collection PubMed
description PURPOSE: The aim of our study was to evaluate the prevalence of different HPV genera—alpha, beta and gamma—in Juvenile onset Recurrent Respiratory Papillomatosis (JoRRP) and examine the association of type and genus-specific viral features with the clinical outcome of disease. METHODS: This retrospective observational study included consecutive patients with JoRRP who were treated in a referral centre between October 2000 and October 2020. All patients underwent cold excision and laser vaporisation of papillomatous lesions. Samples were analysed for the presence of 120 viral genotypes (22 alpha-HPV, 46 beta-HPV, 52 gamma-HPV) using a highly sensitive multiplex genotyping assay. RESULTS: Twenty patients with JoRRP, aged 0.3–11 years, were included, with a median follow-up of 13.5 years. All samples were HPV DNA positive: 20 (100%) for alpha-HPV DNA; 7 (35%) for beta—HPV DNA; 0 for gamma-HPV DNA. Three groups were defined according to the number of infections: seven cases (35%) with HPV mono-infection; ten cases (50%) with HPV double-infection; three cases (15%) with ≥ 3 HPV infections. At diagnosis, patients with ≥ 3 HPV infections reported higher median Derkay’s score than those with mono-infection (21 vs 14, P = 0.018). Number of HPV infections was also associated with clinical outcomes, with an average of 0.5 surgical procedures/year in patients with mono-infection, 1.2 for double-infection, 2.6 for ≥ 3 infections (P = 0.006). CONCLUSION: Despite the small sample size, these preliminary data support an association between the number of different alpha and beta HPV co-infections and the clinical severity of the disease.
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spelling pubmed-87383602022-01-20 Clinical implications of alpha, beta, and gamma HPV infection in juvenile onset recurrent respiratory papillomatosis Bertinazzi, Martina Gheit, Tarik Polesel, Jerry McKay-Chopin, Sandrine Cutrone, Cesare Sari, Marianna Sbaraglia, Marta Tos, Angelo Paolo Dei Nicolai, Piero Tommasino, Massimo Boscolo-Rizzo, Paolo Eur Arch Otorhinolaryngol Laryngology PURPOSE: The aim of our study was to evaluate the prevalence of different HPV genera—alpha, beta and gamma—in Juvenile onset Recurrent Respiratory Papillomatosis (JoRRP) and examine the association of type and genus-specific viral features with the clinical outcome of disease. METHODS: This retrospective observational study included consecutive patients with JoRRP who were treated in a referral centre between October 2000 and October 2020. All patients underwent cold excision and laser vaporisation of papillomatous lesions. Samples were analysed for the presence of 120 viral genotypes (22 alpha-HPV, 46 beta-HPV, 52 gamma-HPV) using a highly sensitive multiplex genotyping assay. RESULTS: Twenty patients with JoRRP, aged 0.3–11 years, were included, with a median follow-up of 13.5 years. All samples were HPV DNA positive: 20 (100%) for alpha-HPV DNA; 7 (35%) for beta—HPV DNA; 0 for gamma-HPV DNA. Three groups were defined according to the number of infections: seven cases (35%) with HPV mono-infection; ten cases (50%) with HPV double-infection; three cases (15%) with ≥ 3 HPV infections. At diagnosis, patients with ≥ 3 HPV infections reported higher median Derkay’s score than those with mono-infection (21 vs 14, P = 0.018). Number of HPV infections was also associated with clinical outcomes, with an average of 0.5 surgical procedures/year in patients with mono-infection, 1.2 for double-infection, 2.6 for ≥ 3 infections (P = 0.006). CONCLUSION: Despite the small sample size, these preliminary data support an association between the number of different alpha and beta HPV co-infections and the clinical severity of the disease. Springer Berlin Heidelberg 2021-08-28 2022 /pmc/articles/PMC8738360/ /pubmed/34453571 http://dx.doi.org/10.1007/s00405-021-07040-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Laryngology
Bertinazzi, Martina
Gheit, Tarik
Polesel, Jerry
McKay-Chopin, Sandrine
Cutrone, Cesare
Sari, Marianna
Sbaraglia, Marta
Tos, Angelo Paolo Dei
Nicolai, Piero
Tommasino, Massimo
Boscolo-Rizzo, Paolo
Clinical implications of alpha, beta, and gamma HPV infection in juvenile onset recurrent respiratory papillomatosis
title Clinical implications of alpha, beta, and gamma HPV infection in juvenile onset recurrent respiratory papillomatosis
title_full Clinical implications of alpha, beta, and gamma HPV infection in juvenile onset recurrent respiratory papillomatosis
title_fullStr Clinical implications of alpha, beta, and gamma HPV infection in juvenile onset recurrent respiratory papillomatosis
title_full_unstemmed Clinical implications of alpha, beta, and gamma HPV infection in juvenile onset recurrent respiratory papillomatosis
title_short Clinical implications of alpha, beta, and gamma HPV infection in juvenile onset recurrent respiratory papillomatosis
title_sort clinical implications of alpha, beta, and gamma hpv infection in juvenile onset recurrent respiratory papillomatosis
topic Laryngology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8738360/
https://www.ncbi.nlm.nih.gov/pubmed/34453571
http://dx.doi.org/10.1007/s00405-021-07040-9
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