PTCH1 mutation promotes antitumor immunity and the response to immune checkpoint inhibitors in colorectal cancer patients

Immunotherapy has emerged as an effective therapeutic strategy for various cancers, including colorectal cancer (CRC), but only a subset of MSI-H patients can benefit from such therapy. Patched1 (PTCH1) is a frequently altered gene in CRCs and its mutations contribute to unregulated Hedgehog (Hh) si...

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Detalles Bibliográficos
Autores principales: Wang, Yanni, Chen, Huan, Jiao, Xi, Wu, Lihong, Yang, Ying, Zhang, Jiao, Wu, Lijia, Liu, Chang, Zhuo, Na, Li, Shuang, Gong, Jifang, Li, Jian, Zhang, Xiaotian, Wang, Xicheng, Peng, Zhi, Qi, Changsong, Wang, Zhenghang, Li, Jie, Li, Yan, Lu, Zhihao, Zhang, Henghui, Shen, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8738454/
https://www.ncbi.nlm.nih.gov/pubmed/34028566
http://dx.doi.org/10.1007/s00262-021-02966-9

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