Cargando…

Inhibition of IKKβ/NF-κB signaling facilitates tendinopathy healing by rejuvenating inflamm-aging induced tendon-derived stem/progenitor cell senescence

Degenerative rotator cuff tendinopathy (RCT) is a chronic tendon disease caused by degeneration and inflammation, which often affects the elderly population. Mesenchymal stem cell senescence is generally recognized as an important pathophysiological mechanism in many age-related skeletal diseases. H...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Chongyang, Zhou, Zhekun, Song, Wei, Cai, Zhuochang, Ding, Zhenyu, Chen, Daoyun, Xia, Fangfang, He, Yaohua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8738957/ https://www.ncbi.nlm.nih.gov/pubmed/35036066 http://dx.doi.org/10.1016/j.omtn.2021.12.026

Ejemplares similares

Prim-O-glucosylcimifugin ameliorates aging-impaired endogenous tendon regeneration by rejuvenating senescent tendon stem/progenitor cells
por: Wang, Yu, et al.
Publicado: (2023)

Tendon stem/progenitor cell ageing: Modulation and rejuvenation
por: Dai, Guang-Chun, et al.
Publicado: (2019)

Therapeutic Roles of Tendon Stem/Progenitor Cells in Tendinopathy
por: Zhang, Xin, et al.
Publicado: (2016)

Advanced glycation end productions and tendon stem/progenitor cells in pathogenesis of diabetic tendinopathy
por: Shi, Liu, et al.
Publicado: (2021)

The Functions and Mechanisms of Tendon Stem/Progenitor Cells in Tendon Healing
por: Lu, Jingwei, et al.
Publicado: (2023)

Rejuvenation of Senescent Endothelial Progenitor Cells by Extracellular Vesicles Derived From Mesenchymal Stromal Cells
por: Wang, Liyong, et al.
Publicado: (2020)

Patellar tendon: From tendinopathy to rupture
por: Rosso, Federica, et al.
Publicado: (2015)

Cellular senescence, rejuvenation and potential immortality
por: Sheldrake, A. Rupert
Publicado: (2022)

AQP1 modulates tendon stem/progenitor cells senescence during tendon aging
por: Chen, Minhao, et al.
Publicado: (2020)

S-Phase Kinase-associated Protein-2 Rejuvenates Senescent Endothelial Progenitor Cells and Induces Angiogenesis in Vivo
por: Wang, Hsueh-Hsiao, et al.
Publicado: (2020)

Adult progenitor rejuvenation with embryonic factors
por: Wang, Peng, et al.
Publicado: (2023)

Achilles Tendon Lesions – Part 1: Tendinopathies
por: Mansur, Nacime Salomão Barbachan, et al.
Publicado: (2020)

Editorial: Mesenchymal Stem Cell Senescence and Rejuvenation
por: Zhang, Yuelin, et al.
Publicado: (2021)

Mechanical Overloading Induced-Activation of mTOR Signaling in Tendon Stem/Progenitor Cells Contributes to Tendinopathy Development
por: Nie, Daibang, et al.
Publicado: (2021)

Effect of a single injection of autologous conditioned serum (ACS) on tendon healing in equine naturally occurring tendinopathies
por: Geburek, Florian, et al.
Publicado: (2015)

Treatment with Human Amniotic Suspension Allograft Improves Tendon Healing in a Rat Model of Collagenase-Induced Tendinopathy
por: de Girolamo, Laura, et al.
Publicado: (2019)

ggstThe role of tendon microcirculation in Achilles and patellar tendinopathy
por: Knobloch, Karsten
Publicado: (2008)

The Use of Hyaluronic Acid after Tendon Surgery and in Tendinopathies
por: Abate, Michele, et al.
Publicado: (2014)

Staging of diabetic tendinopathy in the calcaneal tendon of Wistar rats
por: de Lacerda Brito, Ana Camila Nobre, et al.
Publicado: (2015)

The Plantaris Muscle Tendon and Its Relationship with the Achilles Tendinopathy
por: Olewnik, Ł., et al.
Publicado: (2018)

TfR1 interacts with the IKK complex and is involved in IKK–NF-κB signalling
por: Kenneth, Niall S., et al.
Publicado: (2012)

Selectively activated PRP exerts differential effects on tendon stem/progenitor cells and tendon healing
por: Zhang, Jianying, et al.
Publicado: (2019)

Adipose-derived stem cells improve tendon repair and prevent ectopic ossification in tendinopathy by inhibiting inflammation and inducing neovascularization in the early stage of tendon healing
por: Kokubu, Saeko, et al.
Publicado: (2020)

Bilateral changes in tendon structure of patients diagnosed with unilateral insertional or midportion achilles tendinopathy or patellar tendinopathy
por: Rabello, Lucas Maciel, et al.
Publicado: (2019)

Adipose Stem Cell-Derived Exosomes As a Macrophage-Based Treatment for Chronic Rotator Cuff Tendinopathy: From a Mouse Model to a Study in Human Tissue
por: Yu, Weilin, et al.
Publicado: (2021)

Engineering bioactive nanoparticles to rejuvenate vascular progenitor cells
por: Bui, Loan, et al.
Publicado: (2022)

IKKβ/NF-κB and the miscreant macrophage
por: Timmer, Anjuli M., et al.
Publicado: (2008)

ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ
por: Zhang, Yu, et al.
Publicado: (2017)

Mechanical and Material Tendon Properties in Patients With Proximal Patellar Tendinopathy
por: Wiesinger, Hans-Peter, et al.
Publicado: (2020)

Introduction of a New Index as an Indicator for Achilles Tendon Tendinopathy
por: Wirth, Stephan, et al.
Publicado: (2019)

The impact of nutrition on tendon health and tendinopathy: a systematic review
por: Hijlkema, Aveline, et al.
Publicado: (2022)

Skeletal stem cells and their contribution to skeletal fragility: senescence and rejuvenation
por: Aldahmash, Abdullah
Publicado: (2015)

Mesenchymal Stem Cell Senescence and Rejuvenation: Current Status and Challenges
por: Zhou, Xueke, et al.
Publicado: (2020)

Tendinopathy of the long head of the biceps tendon: histopathologic analysis of the extra-articular biceps tendon and tenosynovium
por: Streit, Jonathan J, et al.
Publicado: (2015)

Noncanonical Wnt5a signaling regulates tendon stem/progenitor cells senescence
por: Chen, Minhao, et al.
Publicado: (2021)

Rapamycin Treatment of Tendon Stem/Progenitor Cells Reduces Cellular Senescence by Upregulating Autophagy
por: Nie, Daibang, et al.
Publicado: (2021)

Human embryonic stem cell-derived exosomes promote pressure ulcer healing in aged mice by rejuvenating senescent endothelial cells
por: Chen, Bi, et al.
Publicado: (2019)

Lineage Tracing of Resident Tendon Progenitor Cells during Growth and Natural Healing
por: Dyment, Nathaniel A., et al.
Publicado: (2014)

Novel small molecule inhibition of IKK/NF‐κB activation reduces markers of senescence and improves healthspan in mouse models of aging
por: Zhang, Lei, et al.
Publicado: (2021)

IKKα and IKKβ Each Function to Regulate NF-κB Activation in the TNF-Induced/Canonical Pathway
por: Adli, Mazhar, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_e12pbkl5d5jfnakr93lfqt98fm