Cargando…

The Critical Modulatory Role of Spiny Stellate Cells in Seizure Onset Based on Dynamic Analysis of a Neural Mass Model

Growing evidence suggests that excitatory neurons in the brain play a significant role in seizure generation. Nonetheless, spiny stellate cells are cortical excitatory non-pyramidal neurons in the brain, whose basic role in seizure occurrence is not well understood. In the present research, we study...

Descripción completa

Detalles Bibliográficos
Autores principales: Tabatabaee, Saba, Bahrami, Fariba, Janahmadi, Mahyar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739215/
https://www.ncbi.nlm.nih.gov/pubmed/35002598
http://dx.doi.org/10.3389/fnins.2021.743720
_version_ 1784629055269634048
author Tabatabaee, Saba
Bahrami, Fariba
Janahmadi, Mahyar
author_facet Tabatabaee, Saba
Bahrami, Fariba
Janahmadi, Mahyar
author_sort Tabatabaee, Saba
collection PubMed
description Growing evidence suggests that excitatory neurons in the brain play a significant role in seizure generation. Nonetheless, spiny stellate cells are cortical excitatory non-pyramidal neurons in the brain, whose basic role in seizure occurrence is not well understood. In the present research, we study the critical role of spiny stellate cells or the excitatory interneurons (EI), for the first time, in epileptic seizure generation using an extended neural mass model inspired by a thalamocortical model originally introduced by another research group. Applying bifurcation analysis on this modified model, we investigated the rich dynamics corresponding to the epileptic seizure onset and transition between interictal and ictal states caused by EI connectivity to other cell types. Our results indicate that the transition between interictal and ictal states (preictal signal) corresponds to a supercritical Hopf bifurcation, and thus, the extended model suggests that before seizure onset, the amplitude and frequency of neural activities gradually increase. Moreover, we showed that (1) the altered function of GABAergic and glutamatergic receptors of EI can cause seizure, and (2) the pathway between the thalamic relay nucleus and EI facilitates the transition from interictal to ictal activity by decreasing the preictal period. Thereafter, we considered both sensory and cortical periodic inputs to study model responses to various harmonic stimulations. Bifurcation analysis of the model, in this case, suggests that the initial state of the model might be the main cause for the transition between interictal and ictal states as the stimulus frequency changes. The extended thalamocortical model shows also that the amplitude jump phenomenon and non-linear resonance behavior result from the preictal state of the modified model. These results can be considered as a step forward to a deeper understanding of the mechanisms underlying the transition from normal activities to epileptic activities.
format Online
Article
Text
id pubmed-8739215
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-87392152022-01-08 The Critical Modulatory Role of Spiny Stellate Cells in Seizure Onset Based on Dynamic Analysis of a Neural Mass Model Tabatabaee, Saba Bahrami, Fariba Janahmadi, Mahyar Front Neurosci Neuroscience Growing evidence suggests that excitatory neurons in the brain play a significant role in seizure generation. Nonetheless, spiny stellate cells are cortical excitatory non-pyramidal neurons in the brain, whose basic role in seizure occurrence is not well understood. In the present research, we study the critical role of spiny stellate cells or the excitatory interneurons (EI), for the first time, in epileptic seizure generation using an extended neural mass model inspired by a thalamocortical model originally introduced by another research group. Applying bifurcation analysis on this modified model, we investigated the rich dynamics corresponding to the epileptic seizure onset and transition between interictal and ictal states caused by EI connectivity to other cell types. Our results indicate that the transition between interictal and ictal states (preictal signal) corresponds to a supercritical Hopf bifurcation, and thus, the extended model suggests that before seizure onset, the amplitude and frequency of neural activities gradually increase. Moreover, we showed that (1) the altered function of GABAergic and glutamatergic receptors of EI can cause seizure, and (2) the pathway between the thalamic relay nucleus and EI facilitates the transition from interictal to ictal activity by decreasing the preictal period. Thereafter, we considered both sensory and cortical periodic inputs to study model responses to various harmonic stimulations. Bifurcation analysis of the model, in this case, suggests that the initial state of the model might be the main cause for the transition between interictal and ictal states as the stimulus frequency changes. The extended thalamocortical model shows also that the amplitude jump phenomenon and non-linear resonance behavior result from the preictal state of the modified model. These results can be considered as a step forward to a deeper understanding of the mechanisms underlying the transition from normal activities to epileptic activities. Frontiers Media S.A. 2021-12-24 /pmc/articles/PMC8739215/ /pubmed/35002598 http://dx.doi.org/10.3389/fnins.2021.743720 Text en Copyright © 2021 Tabatabaee, Bahrami and Janahmadi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Tabatabaee, Saba
Bahrami, Fariba
Janahmadi, Mahyar
The Critical Modulatory Role of Spiny Stellate Cells in Seizure Onset Based on Dynamic Analysis of a Neural Mass Model
title The Critical Modulatory Role of Spiny Stellate Cells in Seizure Onset Based on Dynamic Analysis of a Neural Mass Model
title_full The Critical Modulatory Role of Spiny Stellate Cells in Seizure Onset Based on Dynamic Analysis of a Neural Mass Model
title_fullStr The Critical Modulatory Role of Spiny Stellate Cells in Seizure Onset Based on Dynamic Analysis of a Neural Mass Model
title_full_unstemmed The Critical Modulatory Role of Spiny Stellate Cells in Seizure Onset Based on Dynamic Analysis of a Neural Mass Model
title_short The Critical Modulatory Role of Spiny Stellate Cells in Seizure Onset Based on Dynamic Analysis of a Neural Mass Model
title_sort critical modulatory role of spiny stellate cells in seizure onset based on dynamic analysis of a neural mass model
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739215/
https://www.ncbi.nlm.nih.gov/pubmed/35002598
http://dx.doi.org/10.3389/fnins.2021.743720
work_keys_str_mv AT tabatabaeesaba thecriticalmodulatoryroleofspinystellatecellsinseizureonsetbasedondynamicanalysisofaneuralmassmodel
AT bahramifariba thecriticalmodulatoryroleofspinystellatecellsinseizureonsetbasedondynamicanalysisofaneuralmassmodel
AT janahmadimahyar thecriticalmodulatoryroleofspinystellatecellsinseizureonsetbasedondynamicanalysisofaneuralmassmodel
AT tabatabaeesaba criticalmodulatoryroleofspinystellatecellsinseizureonsetbasedondynamicanalysisofaneuralmassmodel
AT bahramifariba criticalmodulatoryroleofspinystellatecellsinseizureonsetbasedondynamicanalysisofaneuralmassmodel
AT janahmadimahyar criticalmodulatoryroleofspinystellatecellsinseizureonsetbasedondynamicanalysisofaneuralmassmodel