Half-dose glucarpidase as efficient rescue for toxic methotrexate levels in patients with acute kidney injury

PURPOSE: High-dose methotrexate (HDMTX)-associated acute kidney injury with delayed MTX clearance has been linked to an excess in MTX-induced toxicities. Glucarpidase is a recombinant enzyme that rapidly hydrolyzes MTX into non-toxic metabolites. The recommended dose of glucarpidase is 50 U/kg, whic...

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Detalles Bibliográficos
Autores principales: Heuschkel, Sandra, Kretschmann, Theresa, Teipel, Raphael, von Bonin, Simone, Richter, Stephan, Quick, Susanne, Alakel, Nael, Röllig, Christoph, Balaian, Ekaterina, Kroschinsky, Frank, Knoth, Holger, Bornhäuser, Martin, von Bonin, Malte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739299/
https://www.ncbi.nlm.nih.gov/pubmed/34669022
http://dx.doi.org/10.1007/s00280-021-04361-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739299/
https://www.ncbi.nlm.nih.gov/pubmed/34669022
http://dx.doi.org/10.1007/s00280-021-04361-8

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