Hepatocyte generation in liver homeostasis, repair, and regeneration

The liver has remarkable capability to regenerate, employing mechanism to ensure the stable liver-to-bodyweight ratio for body homeostasis. The source of this regenerative capacity has received great attention over the past decade yet still remained controversial currently. Deciphering the sources f...

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Detalles Bibliográficos
Autores principales: Pu, Wenjuan, Zhou, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739411/
https://www.ncbi.nlm.nih.gov/pubmed/34989894
http://dx.doi.org/10.1186/s13619-021-00101-8
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author Pu, Wenjuan
Zhou, Bin
author_facet Pu, Wenjuan
Zhou, Bin
author_sort Pu, Wenjuan
collection PubMed
description The liver has remarkable capability to regenerate, employing mechanism to ensure the stable liver-to-bodyweight ratio for body homeostasis. The source of this regenerative capacity has received great attention over the past decade yet still remained controversial currently. Deciphering the sources for hepatocytes provides the basis for understanding tissue regeneration and repair, and also illustrates new potential therapeutic targets for treating liver diseases. In this review, we describe recent advances in genetic lineage tracing studies over liver stem cells, hepatocyte proliferation, and cell lineage conversions or cellular reprogramming. This review will also evaluate the technical strengths and limitations of methods used for studies on hepatocyte generation and cell fate plasticity in liver homeostasis, repair and regeneration.
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spelling pubmed-87394112022-01-20 Hepatocyte generation in liver homeostasis, repair, and regeneration Pu, Wenjuan Zhou, Bin Cell Regen Review The liver has remarkable capability to regenerate, employing mechanism to ensure the stable liver-to-bodyweight ratio for body homeostasis. The source of this regenerative capacity has received great attention over the past decade yet still remained controversial currently. Deciphering the sources for hepatocytes provides the basis for understanding tissue regeneration and repair, and also illustrates new potential therapeutic targets for treating liver diseases. In this review, we describe recent advances in genetic lineage tracing studies over liver stem cells, hepatocyte proliferation, and cell lineage conversions or cellular reprogramming. This review will also evaluate the technical strengths and limitations of methods used for studies on hepatocyte generation and cell fate plasticity in liver homeostasis, repair and regeneration. Springer Singapore 2022-01-06 /pmc/articles/PMC8739411/ /pubmed/34989894 http://dx.doi.org/10.1186/s13619-021-00101-8 Text en © The Author(s) 2022, corrected publication 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Pu, Wenjuan
Zhou, Bin
Hepatocyte generation in liver homeostasis, repair, and regeneration
title Hepatocyte generation in liver homeostasis, repair, and regeneration
title_full Hepatocyte generation in liver homeostasis, repair, and regeneration
title_fullStr Hepatocyte generation in liver homeostasis, repair, and regeneration
title_full_unstemmed Hepatocyte generation in liver homeostasis, repair, and regeneration
title_short Hepatocyte generation in liver homeostasis, repair, and regeneration
title_sort hepatocyte generation in liver homeostasis, repair, and regeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739411/
https://www.ncbi.nlm.nih.gov/pubmed/34989894
http://dx.doi.org/10.1186/s13619-021-00101-8
work_keys_str_mv AT puwenjuan hepatocytegenerationinliverhomeostasisrepairandregeneration
AT zhoubin hepatocytegenerationinliverhomeostasisrepairandregeneration

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