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Real-world data in elderly men from Yokosuka City 15 years after introducing prostate-specific antigen-based population screening.
Mass screening based on prostate-specific antigen (PSA) reduces mortality in prostate cancer. However, the effectiveness of this screening in the elderly has not been demonstrated. In the city of Yokosuka, Japan, PSA screening has been conducted since 2001 and the present study examined the real-wor...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739438/ https://www.ncbi.nlm.nih.gov/pubmed/35003736 http://dx.doi.org/10.3892/mco.2021.2471 |
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author | Nirei, Takuma Tabei, Tadashi Sakai, Naoki Koh, Hideshige Yoshida, Minoru Fujikawa, Atsushi Ito, Hiroki Tsutsumi, Sohgo Furuhata, Souichi Noguchi, Sumio Taguri, Masataka Kobayashi, Kazuki |
author_facet | Nirei, Takuma Tabei, Tadashi Sakai, Naoki Koh, Hideshige Yoshida, Minoru Fujikawa, Atsushi Ito, Hiroki Tsutsumi, Sohgo Furuhata, Souichi Noguchi, Sumio Taguri, Masataka Kobayashi, Kazuki |
author_sort | Nirei, Takuma |
collection | PubMed |
description | Mass screening based on prostate-specific antigen (PSA) reduces mortality in prostate cancer. However, the effectiveness of this screening in the elderly has not been demonstrated. In the city of Yokosuka, Japan, PSA screening has been conducted since 2001 and the present study examined the real-world status of PSA-based population screening in the elderly. It retrospectively evaluated 1,117 prostate cancer patients >75 years of age. The patients were divided into two groups: The screened group comprising patients diagnosed by PSA-based population screening or workplace screening and PSA follow-up patients at urology clinics; and the non-screened group comprising patients detected by other methods. Overall survival (OS), cancer-specific survival (CSS) and factors contributing to shorter CSS between the groups were compared. In patients >75 years of age, the screened group had significantly longer OS (171 vs. 154 months; P=0.019) and CSS (median not reached; P=0.020) but screening was not an independent factor associated with prolonged OS or CSS on multivariate analysis. The factors contributing to shorten CSS in the elderly were ≥T3 (odds ratio: 3.301 [1.704-6.369], P<0.001), M1 (odds ratio: 4.856 [2.809-8.393], P<0.001) and Gleason score ≥8 (odds ratio: 4.691 [2.479-8.876], P<0.001). In those with metastasis, PSA screening was not associated with prolonged OS or CSS. Real-world data 15 years after introducing PSA-based population screening was not an independent factor for both OS and CSS in multivariate analyses for patients >75 years of age. |
format | Online Article Text |
id | pubmed-8739438 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-87394382022-01-08 Real-world data in elderly men from Yokosuka City 15 years after introducing prostate-specific antigen-based population screening. Nirei, Takuma Tabei, Tadashi Sakai, Naoki Koh, Hideshige Yoshida, Minoru Fujikawa, Atsushi Ito, Hiroki Tsutsumi, Sohgo Furuhata, Souichi Noguchi, Sumio Taguri, Masataka Kobayashi, Kazuki Mol Clin Oncol Articles Mass screening based on prostate-specific antigen (PSA) reduces mortality in prostate cancer. However, the effectiveness of this screening in the elderly has not been demonstrated. In the city of Yokosuka, Japan, PSA screening has been conducted since 2001 and the present study examined the real-world status of PSA-based population screening in the elderly. It retrospectively evaluated 1,117 prostate cancer patients >75 years of age. The patients were divided into two groups: The screened group comprising patients diagnosed by PSA-based population screening or workplace screening and PSA follow-up patients at urology clinics; and the non-screened group comprising patients detected by other methods. Overall survival (OS), cancer-specific survival (CSS) and factors contributing to shorter CSS between the groups were compared. In patients >75 years of age, the screened group had significantly longer OS (171 vs. 154 months; P=0.019) and CSS (median not reached; P=0.020) but screening was not an independent factor associated with prolonged OS or CSS on multivariate analysis. The factors contributing to shorten CSS in the elderly were ≥T3 (odds ratio: 3.301 [1.704-6.369], P<0.001), M1 (odds ratio: 4.856 [2.809-8.393], P<0.001) and Gleason score ≥8 (odds ratio: 4.691 [2.479-8.876], P<0.001). In those with metastasis, PSA screening was not associated with prolonged OS or CSS. Real-world data 15 years after introducing PSA-based population screening was not an independent factor for both OS and CSS in multivariate analyses for patients >75 years of age. D.A. Spandidos 2022-02 2021-12-20 /pmc/articles/PMC8739438/ /pubmed/35003736 http://dx.doi.org/10.3892/mco.2021.2471 Text en Copyright: © Nirei et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Nirei, Takuma Tabei, Tadashi Sakai, Naoki Koh, Hideshige Yoshida, Minoru Fujikawa, Atsushi Ito, Hiroki Tsutsumi, Sohgo Furuhata, Souichi Noguchi, Sumio Taguri, Masataka Kobayashi, Kazuki Real-world data in elderly men from Yokosuka City 15 years after introducing prostate-specific antigen-based population screening. |
title | Real-world data in elderly men from Yokosuka City 15 years after introducing prostate-specific antigen-based population screening. |
title_full | Real-world data in elderly men from Yokosuka City 15 years after introducing prostate-specific antigen-based population screening. |
title_fullStr | Real-world data in elderly men from Yokosuka City 15 years after introducing prostate-specific antigen-based population screening. |
title_full_unstemmed | Real-world data in elderly men from Yokosuka City 15 years after introducing prostate-specific antigen-based population screening. |
title_short | Real-world data in elderly men from Yokosuka City 15 years after introducing prostate-specific antigen-based population screening. |
title_sort | real-world data in elderly men from yokosuka city 15 years after introducing prostate-specific antigen-based population screening. |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739438/ https://www.ncbi.nlm.nih.gov/pubmed/35003736 http://dx.doi.org/10.3892/mco.2021.2471 |
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