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HIV-child with disseminated Talaromyces Marneffei (Penicillium marneffei) infection: a rare severe case report

BACKGROUND: Talaromyces Marneffei (Penicillium marneffei, T.marneffei) has been frequently reported in patients with adult acquired immunodeficiency syndrome. Still, cases of children with HIV combined with T.marneffei infection are very rare. This report describes the case of a HIV-child who is a g...

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Autores principales: Hu, Wei, Yu, Xiao-hong, Wei, Wei-qin, Xiang, Xuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739672/
https://www.ncbi.nlm.nih.gov/pubmed/34996393
http://dx.doi.org/10.1186/s12887-021-03100-5
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author Hu, Wei
Yu, Xiao-hong
Wei, Wei-qin
Xiang, Xuan
author_facet Hu, Wei
Yu, Xiao-hong
Wei, Wei-qin
Xiang, Xuan
author_sort Hu, Wei
collection PubMed
description BACKGROUND: Talaromyces Marneffei (Penicillium marneffei, T.marneffei) has been frequently reported in patients with adult acquired immunodeficiency syndrome. Still, cases of children with HIV combined with T.marneffei infection are very rare. This report describes the case of a HIV-child who is a girl from China. Her special clinical manifestations and laboratory diagnosis results can provide clinicians with the basis for diagnosis and treatment of T.marneffei related rare diseases. CASE PRESNTATION: We reported a single case of 7-year-old Chinese female patient who presented with fever, abdominal pain, multiple lymphadenopathy, hepatosplenomegaly, left lower extremity ecchymosis, and bloody stool. The patient received anti-inflammatory therapy; however, her symptoms did not improve. Consequently, she was diagnosed with T.marneffei and HIV infection; it was also confirmed that her mother did not undergo HIV blocking therapy during pregnancy. Yet, the child’s family refused all treatment, after which the child was discharged from the hospital. The patient died a few days later. CONCLUSION: This case suggested that children with AIDS suffering from fever, lymphadenopathy and coagulation dysfunction, penicilliosis should be suspected. Clinicians should diagnose the disease early through laboratory and imaging results, which can help reduce the mortality, prolong the survival time and improve the quality of life of children.
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spelling pubmed-87396722022-01-07 HIV-child with disseminated Talaromyces Marneffei (Penicillium marneffei) infection: a rare severe case report Hu, Wei Yu, Xiao-hong Wei, Wei-qin Xiang, Xuan BMC Pediatr Case Report BACKGROUND: Talaromyces Marneffei (Penicillium marneffei, T.marneffei) has been frequently reported in patients with adult acquired immunodeficiency syndrome. Still, cases of children with HIV combined with T.marneffei infection are very rare. This report describes the case of a HIV-child who is a girl from China. Her special clinical manifestations and laboratory diagnosis results can provide clinicians with the basis for diagnosis and treatment of T.marneffei related rare diseases. CASE PRESNTATION: We reported a single case of 7-year-old Chinese female patient who presented with fever, abdominal pain, multiple lymphadenopathy, hepatosplenomegaly, left lower extremity ecchymosis, and bloody stool. The patient received anti-inflammatory therapy; however, her symptoms did not improve. Consequently, she was diagnosed with T.marneffei and HIV infection; it was also confirmed that her mother did not undergo HIV blocking therapy during pregnancy. Yet, the child’s family refused all treatment, after which the child was discharged from the hospital. The patient died a few days later. CONCLUSION: This case suggested that children with AIDS suffering from fever, lymphadenopathy and coagulation dysfunction, penicilliosis should be suspected. Clinicians should diagnose the disease early through laboratory and imaging results, which can help reduce the mortality, prolong the survival time and improve the quality of life of children. BioMed Central 2022-01-07 /pmc/articles/PMC8739672/ /pubmed/34996393 http://dx.doi.org/10.1186/s12887-021-03100-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Hu, Wei
Yu, Xiao-hong
Wei, Wei-qin
Xiang, Xuan
HIV-child with disseminated Talaromyces Marneffei (Penicillium marneffei) infection: a rare severe case report
title HIV-child with disseminated Talaromyces Marneffei (Penicillium marneffei) infection: a rare severe case report
title_full HIV-child with disseminated Talaromyces Marneffei (Penicillium marneffei) infection: a rare severe case report
title_fullStr HIV-child with disseminated Talaromyces Marneffei (Penicillium marneffei) infection: a rare severe case report
title_full_unstemmed HIV-child with disseminated Talaromyces Marneffei (Penicillium marneffei) infection: a rare severe case report
title_short HIV-child with disseminated Talaromyces Marneffei (Penicillium marneffei) infection: a rare severe case report
title_sort hiv-child with disseminated talaromyces marneffei (penicillium marneffei) infection: a rare severe case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739672/
https://www.ncbi.nlm.nih.gov/pubmed/34996393
http://dx.doi.org/10.1186/s12887-021-03100-5
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